{"id":"W4285365650","doi":"10.26434/chemrxiv-2021-c7xz5-v2","title":"Impairing Proliferation of Glioblastoma Multiforme with CD44+ Selective Conjugated Polymer Nanoparticles","year":2021,"lang":"en","type":"preprint","venue":"ChemRxiv","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; University of Windsor","funders":"Division of Materials Research; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institute of Standards and Technology; Canada Foundation for Innovation; Windsor Cancer Centre Foundation; University of Windsor; U.S. Department of Commerce; National Science Foundation","keywords":"CD44; Hyaluronic acid; Conjugated system; Population; Blood–brain barrier; Cancer research; Biophysics; Cell; Chemistry; Biology; Medicine; Polymer; Biochemistry; Internal medicine; Central nervous system; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000597451,0.0002238671,0.00009670584,0.00009492729,0.00004841545,0.0001080186,0.00007242901,0.000157597,0.0005818534],"category_scores_gemma":[0.00005942706,0.00007029803,0.00009430322,0.00005488148,0.00007566375,0.00008899789,0.0000950843,0.0001501282,0.0001567182],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001609437,"about_ca_system_score_gemma":0.0000980546,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005661848,"about_ca_topic_score_gemma":0.0006397722,"domain_scores_codex":[0.9999636,0.00000496937,0.000001977746,0.000009846364,0.00001078271,0.000008837208],"domain_scores_gemma":[0.9999814,0.0000042296,0.000005483101,0.000002001247,0.000002843432,0.000003993567],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002245367,0.000009298029,0.00003093774,0.00001599348,0.000001293612,0.00001340513,0.000004254634,0.00007380266,0.9986473,0.00005056868,0.00002865208,0.001102077],"study_design_scores_gemma":[0.000005243744,0.0001686986,0.0003670829,0.000001102231,0.00000381277,0.00004100295,0.000001668604,0.0007716771,0.9978139,0.000009820982,0.0008147624,0.000001168309],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944022,0.000637412,0.002916956,0.00005690273,0.00001841523,0.00002869849,0.0001067856,0.00007355043,0.001758986],"genre_scores_gemma":[0.9919552,0.000626582,0.004007299,0.00002990135,0.000007042804,0.00003364631,0.0001709876,0.00001907249,0.003150285],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005818534,"threshold_uncertainty_score":0.001946509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01435935541417708,"score_gpt":0.2590684856037726,"score_spread":0.2447091301895955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}