{"id":"W4285368687","doi":"10.1161/atvb.41.suppl_1.123","title":"Abstract 123: Intestinal Deletion Of 3-hydroxy-3-methylglutaryl-coenzyme A Reductase Promotes Expansion Of The Resident Stem Cell Compartment","year":2021,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"","keywords":"Biology; Cholesterol; Mevalonate pathway; Sterol; Reductase; Chylomicron; Sterol regulatory element-binding protein; HMG-CoA reductase; Internal medicine; Crypt; Endocrinology; Small intestine; Reabsorption; Biochemistry; Enzyme; Very low-density lipoprotein; Lipoprotein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001502257,0.0005866804,0.00042598,0.0004639925,0.0002425617,0.0006042168,0.0004070208,0.0005639661,0.01598593],"category_scores_gemma":[0.00011865,0.0002981366,0.0005077634,0.000268854,0.0004991509,0.0003795566,0.0004306909,0.001602755,0.004962167],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002751495,"about_ca_system_score_gemma":0.0003486204,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006659498,"about_ca_topic_score_gemma":0.0007905007,"domain_scores_codex":[0.9996293,0.00002793434,0.00004970383,0.00008510499,0.0001415974,0.00006647024],"domain_scores_gemma":[0.999608,0.00003829818,0.0001126734,0.00003358647,0.00003970201,0.0001677099],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001457301,0.00003935642,0.0001471023,0.00006024671,0.000005895572,0.0001219557,0.00001366805,0.00002648648,0.9976296,0.0001528901,0.0002633642,0.001393614],"study_design_scores_gemma":[0.00005238252,0.0003786435,0.005576037,0.00002444072,0.00003163235,0.0006348912,0.00006067411,0.0003828409,0.9828546,0.00007452907,0.00992202,0.000007334719],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9453432,0.004180154,0.01419096,0.001005171,0.0005697055,0.0002383542,0.01209657,0.001975066,0.02040079],"genre_scores_gemma":[0.9223055,0.002637628,0.005891068,0.0003804802,0.00009696356,0.0002298622,0.009858067,0.0005484628,0.058052],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01598593,"threshold_uncertainty_score":0.0534783,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02378564092003206,"score_gpt":0.2593023693232371,"score_spread":0.2355167284032051,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}