{"id":"W4285369373","doi":"10.1161/atvb.41.suppl_1.mp09","title":"Abstract MP09: MLKL (Mixed Lineage Kinase Domain-like Protein) Is A Novel Regulator Of The Splenic Microenvironment That Restricts Hematopoiesis During Atherosclerosis","year":2021,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Atherosclerosis and Cardiovascular Diseases","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Montreal Heart Institute; Ottawa Heart Institute","funders":"","keywords":"Necroptosis; Haematopoiesis; Bone marrow; Myeloid; Progenitor cell; Spleen; Biology; Cancer research; Hematopoietic stem cell; Megakaryocyte; Cell biology; Stem cell; Immunology; Programmed cell death; Apoptosis; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008438751,0.0004691502,0.0002200302,0.0001930531,0.0001807876,0.0003610938,0.0002552102,0.0002977858,0.002379052],"category_scores_gemma":[0.00007632939,0.000106088,0.0001786554,0.0001639819,0.000244566,0.0002179048,0.0002713108,0.0007681088,0.0008676904],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003307415,"about_ca_system_score_gemma":0.0001220564,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002003158,"about_ca_topic_score_gemma":0.0002065323,"domain_scores_codex":[0.9998299,0.00001888284,0.00001477883,0.00005122024,0.00004936331,0.0000358743],"domain_scores_gemma":[0.9999079,0.000006297555,0.00003771915,0.000006489169,0.000009197181,0.0000324577],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001181931,0.00001092708,0.0001820562,0.00003734969,0.00000193274,0.00005692389,0.000004740391,0.00001744971,0.9982704,0.00006554387,0.00008008057,0.001154447],"study_design_scores_gemma":[0.00002695813,0.0003154363,0.005931713,0.000008568358,0.00001833741,0.001000367,0.00002607668,0.0004234063,0.9856926,0.00006951488,0.006481527,0.000005564498],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9782308,0.006542702,0.008698792,0.0005311672,0.0001465613,0.00005840285,0.002311828,0.0004312638,0.003048545],"genre_scores_gemma":[0.9861844,0.001281928,0.003923644,0.0001685899,0.00005000542,0.00005367439,0.001999747,0.00004797321,0.006290055],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002379052,"threshold_uncertainty_score":0.00795877,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02340565252526328,"score_gpt":0.2195151044435082,"score_spread":0.196109451918245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}