{"id":"W4285370686","doi":"10.1161/atvb.41.suppl_1.p176","title":"Abstract P176: Pharmacological Inhibition Of Drp1 Dependent Mitochondrial Fission Alleviates Mitochondrial Dysfunction-associated Cell Death In Vascular Smooth Muscle Cells","year":2021,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Mitochondrial fission; Apoptosis; Cell biology; Mitochondrion; Biology; Programmed cell death; Mitochondrial permeability transition pore; Mitochondrial apoptosis-induced channel; Autophagy; Mitochondrial ROS; Vascular smooth muscle; Cytochrome c; Biochemistry; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001349971,0.0008722711,0.0007244436,0.0003807723,0.0003155957,0.0003035971,0.0004338076,0.0005526079,0.01263069],"category_scores_gemma":[0.0001246098,0.0001613114,0.0004560374,0.0003495881,0.00029614,0.000326014,0.0002577077,0.001753698,0.00217774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002521673,"about_ca_system_score_gemma":0.0003962034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003864244,"about_ca_topic_score_gemma":0.0003719008,"domain_scores_codex":[0.9998827,0.00001199214,0.00001280343,0.00002155562,0.0000362188,0.00003470134],"domain_scores_gemma":[0.9999132,0.000009612599,0.00002461057,0.000007637434,0.00001683162,0.00002812428],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002842364,0.00038179,0.0001395143,0.0006535741,0.00003924808,0.0006217622,0.00004671554,0.0001278295,0.9792732,0.0005670047,0.002528133,0.01277883],"study_design_scores_gemma":[0.0006596565,0.00376525,0.004940979,0.00007613464,0.0001219615,0.001511915,0.00007593827,0.0005892991,0.9629022,0.0004613529,0.02487958,0.00001565205],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9251083,0.02772589,0.007023232,0.00386452,0.002170406,0.0003436448,0.008236522,0.0009303795,0.02459704],"genre_scores_gemma":[0.9479777,0.01280553,0.004533252,0.0007386373,0.0005704716,0.0003816985,0.005837452,0.0001056599,0.02704968],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01263069,"threshold_uncertainty_score":0.04225379,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02408109538606892,"score_gpt":0.2617316178961986,"score_spread":0.2376505225101297,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}