{"id":"W4285385597","doi":"10.1126/sciadv.abn4188","title":"Engineered ACE2-Fc counters murine lethal SARS-CoV-2 infection through direct neutralization and Fc-effector activities","year":2022,"lang":"en","type":"article","venue":"Science Advances","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Effector; Neutralization; Receptor; Virology; Angiotensin-converting enzyme 2; Biology; Antibody; Coronavirus; Virus; Immunology; Chemistry; Coronavirus disease 2019 (COVID-19); Medicine; Biochemistry; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005704965,0.0001583386,0.0002236505,0.0002618836,0.0005186115,0.00008431524,0.0001655503,0.0000281443,0.00001250364],"category_scores_gemma":[0.0001919976,0.0001401106,0.00004864713,0.001185743,0.0005765009,0.001318871,0.0001450786,0.0002266794,0.00001330885],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002563528,"about_ca_system_score_gemma":0.0002295528,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002373904,"about_ca_topic_score_gemma":0.00009151996,"domain_scores_codex":[0.9981253,0.00006635273,0.0001560392,0.0004616966,0.0007883844,0.000402298],"domain_scores_gemma":[0.9994778,0.0001293411,0.00006609775,0.0002235948,0.00007591995,0.00002724776],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002564655,0.00009230981,0.01989328,0.0001235486,0.00001387124,0.00002265805,0.0009357276,0.0001124894,0.9730114,0.00008001677,0.0001557728,0.005302402],"study_design_scores_gemma":[0.0007922372,0.0009393424,0.006309028,0.00004088544,0.00001995255,0.00008323703,0.0004107186,0.0009967088,0.8168074,0.00007983102,0.173328,0.0001926708],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950798,0.0009366069,0.0004182446,0.000248746,0.000592079,0.0004129136,0.00002285323,0.0001284129,0.002160313],"genre_scores_gemma":[0.9962367,0.00004446112,0.0001559901,0.00326743,0.000104799,0.0001204818,0.000007194568,0.00001579442,0.00004708406],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1731722,"threshold_uncertainty_score":0.5713546,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03235412301547419,"score_gpt":0.3604745137427843,"score_spread":0.3281203907273101,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}