{"id":"W4285388836","doi":"10.1186/s12883-022-02770-7","title":"Multiple N-of-1 trials to investigate hypoxia therapy in Parkinson’s disease: study rationale and protocol","year":2022,"lang":"en","type":"article","venue":"BMC Neurology","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia, Okanagan Campus; University of British Columbia; Centre for Movement Disorders","funders":"Parkinsonfonden; Radboud Universitair Medisch Centrum; Radboud Universiteit; Michael J. Fox Foundation for Parkinson's Research","keywords":"Medicine; Tolerability; Disease; Parkinson's disease; Randomized controlled trial; Clinical trial; Neurology; Physical medicine and rehabilitation; Physical therapy; Rating scale; Internal medicine; Adverse effect; Psychology; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02299458,0.005546452,0.009030204,0.001783265,0.002629172,0.00338915,0.003041396,0.00691554,0.02447185],"category_scores_gemma":[0.01970917,0.001868423,0.004474002,0.002417031,0.002935182,0.003161185,0.002417391,0.005745064,0.005688733],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002949191,"about_ca_system_score_gemma":0.009518825,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000992442,"about_ca_topic_score_gemma":0.002601113,"domain_scores_codex":[0.9862942,0.008866875,0.001403741,0.001374342,0.001040568,0.0010203],"domain_scores_gemma":[0.9915555,0.002419826,0.001922242,0.001074599,0.00151564,0.001512287],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9102711,0.008539828,0.001642303,0.0199571,0.003548223,0.0003802163,0.0003935987,0.001838297,0.004148103,0.00289264,0.01057937,0.0358092],"study_design_scores_gemma":[0.9045141,0.04351892,0.003434122,0.003160985,0.002736408,0.0001449899,0.0001313695,0.001217908,0.001156002,0.004369464,0.0355072,0.0001085903],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.006934284,0.00216431,0.002546316,0.0006687168,0.0004644595,0.9835344,0.00151641,0.0001181393,0.002053068],"genre_scores_gemma":[0.007568536,0.0006960952,0.002735764,0.0005548085,0.0001168137,0.987283,0.0002606731,0.00001042001,0.0007738803],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.02447185,"threshold_uncertainty_score":0.1216084,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09442137779383811,"score_gpt":0.3432350694005849,"score_spread":0.2488136916067468,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}