{"id":"W4285388898","doi":"10.1038/s41590-022-01262-7","title":"Pre-encoded responsiveness to type I interferon in the peripheral immune system defines outcome of PD1 blockade therapy","year":2022,"lang":"en","type":"article","venue":"Nature Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":51,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Institute for Cancer Research; University of Toronto; Hospital for Sick Children; Princess Margaret Cancer Centre; University Health Network","funders":"CIHR Skin Research Training Centre; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; National Institutes of Health; Government of Canada; U.S. Department of Health and Human Services","keywords":"Blockade; Peripheral; Immune system; Immunology; Medicine; Interferon; Immune checkpoint; Outcome (game theory); Immunotherapy; Receptor; Internal medicine; Mathematics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005126643,0.0002190476,0.0003987833,0.0002548582,0.0001656108,0.0008715758,0.0001428948,0.000306672,0.001520917],"category_scores_gemma":[0.0006328904,0.00009111048,0.0001680713,0.0001404182,0.0002606393,0.0003177305,0.000215521,0.001015171,0.0004460686],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003475671,"about_ca_system_score_gemma":0.0002382964,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001277534,"about_ca_topic_score_gemma":0.0001923093,"domain_scores_codex":[0.9996949,0.0000928929,0.00002225945,0.0000398849,0.00005193703,0.00009805637],"domain_scores_gemma":[0.9997236,0.00009348917,0.00006385806,0.00002859992,0.00002558378,0.00006475108],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01124722,0.001017613,0.0233689,0.0001375822,0.00006779997,0.0003600635,0.0002086423,0.001448751,0.8705673,0.001738877,0.0008723952,0.08896485],"study_design_scores_gemma":[0.0007345471,0.04231602,0.2868752,0.0001204136,0.000428296,0.004530427,0.0005585467,0.009324022,0.6384761,0.003344247,0.01323876,0.00005341335],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931641,0.001328761,0.001121965,0.00009191065,0.00003480606,0.00005270661,0.0001340372,0.00004187008,0.004029845],"genre_scores_gemma":[0.9988701,0.0001852103,0.0001991771,0.00005252171,0.00001227192,0.00002445689,0.00009814369,0.00001030948,0.0005478504],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001520917,"threshold_uncertainty_score":0.005087912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01273776513568818,"score_gpt":0.2718976340343251,"score_spread":0.2591598688986369,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}