{"id":"W4285390874","doi":"10.1038/s42003-022-03654-9","title":"Combined MEK and JAK/STAT3 pathway inhibition effectively decreases SHH medulloblastoma tumor progression","year":2022,"lang":"en","type":"article","venue":"Communications Biology","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Research Institute in Oncology and Hematology; CancerCare Manitoba; Institute of Cancer Research; University of Calgary; Hospital for Sick Children; SickKids Foundation; University of Toronto; Ottawa Hospital; University of Manitoba","funders":"Canadian Institutes of Health Research; Government of Canada; CancerCare Manitoba Foundation; Research Manitoba; Canada Research Chairs; University of Manitoba; Rally Foundation","keywords":"Selumetinib; Medulloblastoma; MEK inhibitor; Cancer research; Sonic hedgehog; MAPK/ERK pathway; Hedgehog signaling pathway; STAT3; Medicine; Biology; Kinase; Signal transduction; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004022645,0.000167438,0.0001949078,0.00008691545,0.000835423,0.00001388138,0.0003925659,0.00007253107,0.00002047159],"category_scores_gemma":[0.0004172447,0.0001627543,0.00005953032,0.0001609853,0.0004805927,0.00000403692,0.001700596,0.0002027052,0.000005669888],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003489287,"about_ca_system_score_gemma":0.0001087832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002048267,"about_ca_topic_score_gemma":0.00004443593,"domain_scores_codex":[0.9982998,0.0008169094,0.0002363138,0.0003453691,0.00007345246,0.0002281054],"domain_scores_gemma":[0.9986774,0.0001581061,0.0001394094,0.0008435814,0.0001020207,0.00007953536],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002474622,0.0004575541,0.01660985,0.00002392163,0.0000996295,0.000005202868,0.0003170867,0.00001122639,0.9670948,0.003732353,0.001075847,0.01032504],"study_design_scores_gemma":[0.005551732,0.009735999,0.0306195,0.0001234316,0.0001415606,0.0003264264,0.002703884,0.0009607618,0.6639193,0.006921058,0.2774857,0.001510672],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925178,0.004932404,0.0004202961,0.0007330668,0.00009037316,0.0004578168,0.0001289183,0.00005520349,0.0006641537],"genre_scores_gemma":[0.9959907,0.0002873424,0.001613144,0.0004763712,0.00003206742,0.0006868117,0.0008473937,0.0000212139,0.00004494814],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3031755,"threshold_uncertainty_score":0.6636925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01834855694010724,"score_gpt":0.2953135076324054,"score_spread":0.2769649506922982,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}