{"id":"W4285391095","doi":"10.1038/s41588-022-01113-z","title":"Genetic regulation of OAS1 nonsense-mediated decay underlies association with COVID-19 hospitalization in patients of European and African ancestries","year":2022,"lang":"en","type":"article","venue":"Nature Genetics","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":138,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Toronto General Hospital; University Health Network","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; National Center for Advancing Translational Sciences; National Institute of Neurological Disorders and Stroke; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; Oxford Nanopore Technologies; Weill Cornell Medical College; National Institute on Aging; Center for Clinical and Translational Science, University of Alabama at Birmingham; Emory Medical Care Foundation; Deutsche Forschungsgemeinschaft; Massachusetts Consortium on Pathogen Readiness; National Human Genome Research Institute; Hellenic Foundation for Research and Innovation; Universidade de São Paulo; European Commission; Seoul National University Bundang Hospital; Wayne and Gladys Valley Foundation; University of Alabama at Birmingham; Kaiser Permanente; University of Alabama; National Cancer Institute; U.S. Department of Health and Human Services; Genomic Health; Emory University; Frederick National Laboratory for Cancer Research; National Institutes of Health; Robert Wood Johnson Foundation; Ellison Medical Foundation","keywords":"Biology; Haplotype; Locus (genetics); Allele; Genetics; Genome-wide association study; Single-nucleotide polymorphism; Nonsense-mediated decay; Disease; Gene; RNA splicing; Genotype; Medicine; RNA; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002454338,0.0002960243,0.0002530005,0.0004424398,0.0002827208,0.0002776709,0.0001676073,0.0003143394,0.003277396],"category_scores_gemma":[0.000737279,0.0001101865,0.0004069679,0.0004103246,0.0002372461,0.0001169409,0.0002059259,0.0003220691,0.0001909211],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001098451,"about_ca_system_score_gemma":0.0001011464,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008857568,"about_ca_topic_score_gemma":0.0008825626,"domain_scores_codex":[0.9997603,0.000060494,0.00002992152,0.0000887553,0.00002404918,0.00003644212],"domain_scores_gemma":[0.9996086,0.00009692473,0.0001818641,0.00003280897,0.00001831936,0.00006157885],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001625532,0.00007616294,0.9442562,0.00002912498,0.0002301785,0.001074933,0.0002261043,0.0001443228,0.04587824,0.000208116,0.0001830174,0.00606806],"study_design_scores_gemma":[0.00002954583,0.0001934529,0.994622,0.000008709287,0.00008809348,0.002011652,0.0001340699,0.0006203511,0.001812711,0.0001421719,0.000330496,0.000006705165],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994331,0.00008537571,0.0002231048,0.00002685692,0.000004271941,0.00000241942,0.00008612849,0.000003179988,0.0001354872],"genre_scores_gemma":[0.999588,0.00002602063,0.0001479067,0.00001371875,0.000005153891,0.000002439746,0.0001003689,0.000003324237,0.0001130413],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003277396,"threshold_uncertainty_score":0.01096398,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006092664110982121,"score_gpt":0.2198298373818403,"score_spread":0.2137371732708581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}