{"id":"W4285391095","doi":"10.1038/s41588-022-01113-z","title":"Genetic regulation of OAS1 nonsense-mediated decay underlies association with COVID-19 hospitalization in patients of European and African ancestries","year":2022,"lang":"en","type":"article","venue":"Nature Genetics","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":138,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Toronto General Hospital; University Health Network","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; National Center for Advancing Translational Sciences; National Institute of Neurological Disorders and Stroke; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; Oxford Nanopore Technologies; Weill Cornell Medical College; National Institute on Aging; Center for Clinical and Translational Science, University of Alabama at Birmingham; Emory Medical Care Foundation; Deutsche Forschungsgemeinschaft; Massachusetts Consortium on Pathogen Readiness; National Human Genome Research Institute; Hellenic Foundation for Research and Innovation; Universidade de São Paulo; European Commission; Seoul National University Bundang Hospital; Wayne and Gladys Valley Foundation; University of Alabama at Birmingham; Kaiser Permanente; University of Alabama; National Cancer Institute; U.S. Department of Health and Human Services; Genomic Health; Emory University; Frederick National Laboratory for Cancer Research; National Institutes of Health; Robert Wood Johnson Foundation; Ellison Medical Foundation","keywords":"Biology; Haplotype; Locus (genetics); Allele; Genetics; Genome-wide association study; Single-nucleotide polymorphism; Nonsense-mediated decay; Disease; Gene; RNA splicing; Genotype; Medicine; RNA; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000205007,0.00008816034,0.0001565409,0.0001540906,0.00007809141,0.00000432445,0.00008453256,0.0001227136,0.0000430806],"category_scores_gemma":[0.0002197374,0.00008268955,0.00001790647,0.0002420226,0.0001055609,0.00002013184,0.00006275504,0.0002075277,0.000001152794],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001064363,"about_ca_system_score_gemma":0.00009553205,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002074615,"about_ca_topic_score_gemma":0.0000308081,"domain_scores_codex":[0.9989523,0.0004584042,0.0002491719,0.0001389529,0.00008107932,0.0001200516],"domain_scores_gemma":[0.9993047,0.0001480495,0.000301951,0.0001172984,0.000116343,0.00001172573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001068879,0.0001674279,0.95719,0.00005067176,0.00008576315,0.00000114579,0.00261274,0.0008676626,0.03648727,0.0001106619,0.0005692325,0.0007885037],"study_design_scores_gemma":[0.001459492,0.0008806782,0.9689536,0.00001234498,0.00002591736,0.000003435541,0.0005988884,0.00001506049,0.02458293,0.0000281673,0.003345865,0.00009363035],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962832,0.002933019,0.00007564702,0.00009564129,0.000156119,0.0001864751,0.00007323625,0.00001136419,0.000185334],"genre_scores_gemma":[0.9992951,0.0001438459,0.0001014021,0.00007274079,0.000003973014,0.000004039105,0.0001915423,0.00001151107,0.0001758758],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01190434,"threshold_uncertainty_score":0.3371982,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006092664110982121,"score_gpt":0.2198298373818403,"score_spread":0.2137371732708581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}