{"id":"W4285394138","doi":"10.1101/2022.07.12.499727","title":"Heterogeneity of RNA editing in mesothelioma and how RNA editing enzyme ADAR2 affects mesothelioma cell growth, response to chemotherapy and tumor microenvironment","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"ADAR; RNA editing; Biology; Mesothelioma; Cancer research; RNA; Tumor microenvironment; microRNA; Medicine; Pathology; Genetics; Gene; Tumor cells","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001458481,0.000160184,0.0001972819,0.0002014552,0.0001520556,0.0003442978,0.0001032324,0.0002292371,0.0007899563],"category_scores_gemma":[0.0001213448,0.0001173111,0.0001917523,0.0001196399,0.0001537398,0.0001428472,0.0001425986,0.0003085754,0.000357834],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000219109,"about_ca_system_score_gemma":0.00008090428,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004280852,"about_ca_topic_score_gemma":0.0005214725,"domain_scores_codex":[0.99986,0.00001728452,0.000007285872,0.00005180906,0.00004129381,0.00002230933],"domain_scores_gemma":[0.9999154,0.00001597594,0.00002481255,0.00001533923,0.00001167637,0.00001686298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003172416,0.000003286085,0.0003644757,0.000007918887,0.000002522139,0.00002069923,0.000007333816,0.0000350023,0.9991295,0.00001715115,0.00001610398,0.0003643987],"study_design_scores_gemma":[0.000004585896,0.00006426207,0.02255716,0.000002704198,0.0000144027,0.0003672939,0.00004175611,0.001294332,0.9736025,0.00007788803,0.001968233,0.000004769919],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905779,0.001905927,0.00528904,0.00009366526,0.00002645709,0.0000148317,0.0008271801,0.0001386641,0.001126309],"genre_scores_gemma":[0.9946031,0.0003816428,0.001997589,0.00002819751,0.000007225053,0.00001439076,0.0007768243,0.00003473961,0.002156229],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007899563,"threshold_uncertainty_score":0.002642691,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006173647757160505,"score_gpt":0.2068835564596592,"score_spread":0.2007099087024987,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}