{"id":"W4285395213","doi":"10.1101/2022.07.12.499729","title":"The CoQ biosynthetic di-iron carboxylate hydroxylase COQ7 is inhibited by in vivo metalation with manganese but remains function by metalation with cobalt","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Coenzyme Q10 studies and effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Manganese; Cobalt; Chemistry; Metalation; Enzyme; Active site; Biochemistry; Stereochemistry; Inorganic chemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006536455,0.0006618004,0.0004997073,0.0001339826,0.0004776557,0.0001542738,0.0003227016,0.0003745257,0.00002713072],"category_scores_gemma":[0.00007579647,0.0005214039,0.0001265245,0.0005447762,0.0002015173,0.00001994315,0.0004347473,0.0005607189,0.000004723959],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002370647,"about_ca_system_score_gemma":0.0002095009,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003212479,"about_ca_topic_score_gemma":0.0001476772,"domain_scores_codex":[0.9969503,0.0003267482,0.0004724,0.001171368,0.0005041616,0.0005750643],"domain_scores_gemma":[0.9979256,0.00006052016,0.0005188233,0.001100039,0.0002392378,0.0001557396],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006585307,0.0001513836,0.006447917,0.0001438691,0.0003983302,0.00001820689,0.00002191308,0.000519955,0.9859856,0.00002078612,0.005631524,0.000001995881],"study_design_scores_gemma":[0.002190017,0.001145354,0.01365564,0.0002185629,0.0006371244,2.688173e-7,0.00007632768,0.001774052,0.9301897,8.589657e-7,0.04866591,0.001446136],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929268,0.003783852,0.0005170799,0.0003131536,0.0003729292,0.001482969,0.0005059233,0.00008289901,0.00001437845],"genre_scores_gemma":[0.997967,0.000751926,0.00007463805,0.000193962,0.0001371078,0.0006173928,0.00002568861,0.0001390252,0.00009324304],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05579584,"threshold_uncertainty_score":0.9997237,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004037952688796655,"score_gpt":0.1857324947759099,"score_spread":0.1816945420871132,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}