{"id":"W4285412042","doi":"10.1007/978-1-0716-2473-9_11","title":"Monitoring Hippo Signaling Pathway Activity Using a Luciferase-Based Large Tumor Suppressor (LATS) Biosensor","year":2022,"lang":"en","type":"article","venue":"Methods in molecular biology","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"","keywords":"Suppressor; Biosensor; Luciferase; Hippo signaling pathway; Cell biology; Cancer research; Chemistry; Biology; Signal transduction; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006573736,0.0007961509,0.0003947613,0.0003794987,0.0003368113,0.0005562837,0.0007957015,0.000823934,0.001130315],"category_scores_gemma":[0.0004187609,0.000294535,0.0003902577,0.0004582231,0.0006333083,0.000524144,0.0004953053,0.001409643,0.0005988094],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001026041,"about_ca_system_score_gemma":0.0004016242,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006835922,"about_ca_topic_score_gemma":0.001050605,"domain_scores_codex":[0.9995016,0.00009915586,0.00002489617,0.0001437145,0.0001493759,0.00008126756],"domain_scores_gemma":[0.9996259,0.0001325144,0.00008147898,0.00003676004,0.0000557944,0.00006755831],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006203906,0.0000378525,0.0001462007,0.00002633388,0.00000493841,0.00001735809,0.00002057536,0.00006776092,0.9986227,0.0001952692,0.00008930941,0.0007098305],"study_design_scores_gemma":[0.000008077328,0.00008370247,0.000496078,0.000002501281,0.000005851491,0.00003522512,0.00002161418,0.002065452,0.9966533,0.00005501847,0.0005672098,0.000006067019],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.8423741,0.0008131571,0.1501303,0.0007959834,0.0001510458,0.00009085201,0.00091671,0.001633312,0.003094432],"genre_scores_gemma":[0.9110528,0.0008835898,0.07821412,0.0002772991,0.00004712976,0.0002932501,0.00146803,0.0001329207,0.007630893],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.001130315,"threshold_uncertainty_score":0.007444441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03569241097204563,"score_gpt":0.36867910780658,"score_spread":0.3329866968345344,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}