{"id":"W4285491367","doi":"10.1038/s43587-022-00241-9","title":"An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer’s disease","year":2022,"lang":"en","type":"article","venue":"Nature Aging","topic":"IL-33, ST2, and ILC Pathways","field":"Immunology and Microbiology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Parkwood Institute; St Joseph's Health Care; University of British Columbia; McGill University; Jewish General Hospital","funders":"Medical Research Council; Yulgilbar Foundation; Shenzhen Knowledge Innovation Program; State Government of Victoria; Alzheimer's Drug Discovery Foundation; University Grants Committee; Dementia Collaborative Research Centres, Australia; Edith Cowan University; Australian Alzheimer's Research Foundation; Innovation and Technology Commission; National Natural Science Foundation of China; Institut National de la Santé et de la Recherche Médicale; Alzheimer's Society; National Health and Medical Research Council; Commonwealth Scientific and Industrial Research Organisation; National Institute on Aging; Alzheimer's Association; Science and Industry Endowment Fund","keywords":"Mendelian randomization; Apolipoprotein E; Biology; TREM2; Disease; Transcriptome; Genome-wide association study; Allele; Mendelian inheritance; Genetic association; Gene; Alzheimer's disease; Genetics; Genotype; Receptor; Single-nucleotide polymorphism; Internal medicine; Medicine; Gene expression; Genetic variants","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001695112,0.0005707133,0.0002487923,0.0003777886,0.0002455429,0.0002763744,0.0001429471,0.0003858842,0.003155984],"category_scores_gemma":[0.0005620605,0.0001428692,0.0002719642,0.0002236067,0.0001714379,0.000117501,0.0001324201,0.0002686664,0.0003085898],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00011208,"about_ca_system_score_gemma":0.00008692897,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008196399,"about_ca_topic_score_gemma":0.0005805494,"domain_scores_codex":[0.9998804,0.00002758088,0.0000096214,0.00004419349,0.00001855769,0.00001955061],"domain_scores_gemma":[0.9998224,0.00003101126,0.0000849752,0.00001621695,0.00001298181,0.00003237217],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.009569381,0.0004715949,0.6679707,0.00009436673,0.0004484168,0.006866962,0.0004877697,0.0002360477,0.2883613,0.0005109144,0.001262448,0.0237202],"study_design_scores_gemma":[0.0001348842,0.0007419941,0.97919,0.00001707643,0.0002890715,0.006837594,0.0001371863,0.00065947,0.01017929,0.0003058301,0.001488456,0.00001918153],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986801,0.0002985941,0.0002477434,0.00009419543,0.00001980327,0.000003431896,0.0001724667,0.00001528722,0.000468405],"genre_scores_gemma":[0.998897,0.00009742055,0.0001450084,0.00004517774,0.00001835511,0.0000038808,0.00009425814,0.000008000183,0.0006910491],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003155984,"threshold_uncertainty_score":0.01055777,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004376617701248551,"score_gpt":0.2057025658481194,"score_spread":0.2013259481468708,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}