{"id":"W4285491367","doi":"10.1038/s43587-022-00241-9","title":"An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer’s disease","year":2022,"lang":"en","type":"article","venue":"Nature Aging","topic":"IL-33, ST2, and ILC Pathways","field":"Immunology and Microbiology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Parkwood Institute; St Joseph's Health Care; University of British Columbia; McGill University; Jewish General Hospital","funders":"Medical Research Council; Yulgilbar Foundation; Shenzhen Knowledge Innovation Program; State Government of Victoria; Alzheimer's Drug Discovery Foundation; University Grants Committee; Dementia Collaborative Research Centres, Australia; Edith Cowan University; Australian Alzheimer's Research Foundation; Innovation and Technology Commission; National Natural Science Foundation of China; Institut National de la Santé et de la Recherche Médicale; Alzheimer's Society; National Health and Medical Research Council; Commonwealth Scientific and Industrial Research Organisation; National Institute on Aging; Alzheimer's Association; Science and Industry Endowment Fund","keywords":"Mendelian randomization; Apolipoprotein E; Biology; TREM2; Disease; Transcriptome; Genome-wide association study; Allele; Mendelian inheritance; Genetic association; Gene; Alzheimer's disease; Genetics; Genotype; Receptor; Single-nucleotide polymorphism; Internal medicine; Medicine; Gene expression; Genetic variants","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002884554,0.0001562986,0.0002381441,0.00009181809,0.0003386721,0.00001089895,0.0002177938,0.0001117804,0.00003371],"category_scores_gemma":[0.00007085835,0.0001063985,0.00004120163,0.0001864717,0.000179539,0.00007247855,0.0001238676,0.0008008119,0.000003229488],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002169975,"about_ca_system_score_gemma":0.00008063355,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001630094,"about_ca_topic_score_gemma":0.00004672968,"domain_scores_codex":[0.9986594,0.0005153887,0.0001642911,0.000296925,0.00007591074,0.0002880394],"domain_scores_gemma":[0.99928,0.0002111334,0.0001306201,0.0003063331,0.00004128245,0.0000306596],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004710713,0.001397158,0.9442462,0.0002795789,0.001138314,0.0002212117,0.02012382,0.001459242,0.01081072,0.001505443,0.001022757,0.01308483],"study_design_scores_gemma":[0.01139851,0.0005338602,0.9767805,0.00008220509,0.0004630011,0.00001615245,0.0005965758,0.0001120093,0.004884864,0.0004222278,0.004352181,0.0003579253],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886914,0.0095654,0.00004663219,0.00004308193,0.0006132981,0.0004901962,0.0004166212,0.00002158396,0.0001118101],"genre_scores_gemma":[0.9994177,0.00004092679,0.00007548704,0.0002656487,0.00001780309,0.00004027005,0.00007661806,0.00001790585,0.00004764548],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03253427,"threshold_uncertainty_score":0.4338807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004376617701248551,"score_gpt":0.2057025658481194,"score_spread":0.2013259481468708,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}