{"id":"W4285492173","doi":"10.1080/15548627.2022.2100615","title":"Feedforward activation of PRKN/parkin","year":2022,"lang":"en","type":"article","venue":"Autophagy","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"PINK1; Parkin; Mitophagy; Autophagy; Ubiquitin ligase; Biology; Parkinson's disease; Cell biology; Mitochondrion; Ubiquitin; Dopaminergic; Neuroscience; Kinase; Disease; Genetics; Internal medicine; Dopamine; Medicine; Gene; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002154191,0.0004665064,0.0003451046,0.0001902407,0.0003158778,0.0004998746,0.0002997386,0.0004021284,0.005035158],"category_scores_gemma":[0.000267194,0.0001617986,0.0003138216,0.000121725,0.0003230873,0.0005124132,0.0007890734,0.000759121,0.001238411],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004568064,"about_ca_system_score_gemma":0.0002435849,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003464882,"about_ca_topic_score_gemma":0.0006528937,"domain_scores_codex":[0.9996377,0.0000278416,0.00001464856,0.0001250249,0.0001225824,0.00007213907],"domain_scores_gemma":[0.9998306,0.00002239646,0.00003597684,0.00001993465,0.00004491323,0.00004611216],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000252677,0.00003045557,0.0003679732,0.0001764881,0.000009021936,0.0001880311,0.0000414553,0.0003389526,0.987951,0.001497092,0.0005503656,0.008596458],"study_design_scores_gemma":[0.00004770218,0.0003286457,0.00790815,0.00004404978,0.00002695651,0.0006514717,0.00006918712,0.005143269,0.9626536,0.002392172,0.02071227,0.00002241606],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8802185,0.01394068,0.06290121,0.001858229,0.0008767608,0.0001955043,0.001818247,0.002431695,0.03575919],"genre_scores_gemma":[0.9835576,0.001839432,0.004930269,0.0002502755,0.00004230042,0.00004121447,0.000330153,0.00005531666,0.008953462],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005035158,"threshold_uncertainty_score":0.01684427,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01662757973075512,"score_gpt":0.2648596496286815,"score_spread":0.2482320698979264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}