{"id":"W4285492173","doi":"10.1080/15548627.2022.2100615","title":"Feedforward activation of PRKN/parkin","year":2022,"lang":"en","type":"article","venue":"Autophagy","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"PINK1; Parkin; Mitophagy; Autophagy; Ubiquitin ligase; Biology; Parkinson's disease; Cell biology; Mitochondrion; Ubiquitin; Dopaminergic; Neuroscience; Kinase; Disease; Genetics; Internal medicine; Dopamine; Medicine; Gene; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00008025176,0.0000751916,0.0001588147,0.00008297449,0.00007649991,0.000002913149,0.00005028451,0.00002238482,0.001226746],"category_scores_gemma":[0.00001952876,0.00007019456,0.00007698195,0.0001592747,0.0000137615,0.00003715771,0.00005170182,0.00007898527,0.00002294548],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001050966,"about_ca_system_score_gemma":0.00008296751,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004070999,"about_ca_topic_score_gemma":3.657935e-7,"domain_scores_codex":[0.9993045,0.0000313859,0.0001283349,0.0001524057,0.0002614897,0.0001219006],"domain_scores_gemma":[0.9996318,0.00001924223,0.00007424834,0.000183857,0.00002642895,0.00006438966],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00464146,0.01146095,0.06163256,0.0007010591,0.003204099,0.001223859,0.003127444,0.0006995508,0.4933439,0.04960954,0.02154949,0.3488061],"study_design_scores_gemma":[0.005503409,0.001416764,0.3780712,0.00003997148,0.00034935,0.0000733937,0.0002228703,0.001085251,0.3696227,0.002488886,0.2409081,0.0002181526],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932148,0.0001862637,0.0001934446,0.0002417494,0.0001332282,0.0002413788,0.00002553194,0.00004919008,0.005714403],"genre_scores_gemma":[0.9969552,0.000006359542,0.0003726898,0.000294871,0.00003196335,0.00007414518,0.00006093664,0.00001355775,0.002190287],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3485879,"threshold_uncertainty_score":0.9996862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01662757973075512,"score_gpt":0.2648596496286815,"score_spread":0.2482320698979264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}