{"id":"W4285492196","doi":"10.1200/jco.21.02615","title":"Using Circulating Tumor DNA in Colorectal Cancer: Current and Evolving Practices","year":2022,"lang":"en","type":"review","venue":"Journal of Clinical Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":276,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of General Medical Sciences","keywords":"Medicine; Circulating tumor DNA; Liquid biopsy; Colorectal cancer; Minimal residual disease; Oncology; Biomarker; Internal medicine; Circulating tumor cell; DNA methylation; Risk stratification; Disease; Personalized medicine; Profiling (computer programming); Precision medicine; Bioinformatics; Cancer; Pathology; Gene; Metastasis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.002889219,0.0002279407,0.002126431,0.0001301856,0.00006284517,0.00002844197,0.0002791849,0.0003498122,0.00005580484],"category_scores_gemma":[0.00957097,0.0001979763,0.0005491074,0.0001300042,0.0001064472,0.000008513523,0.0003609924,0.001310352,4.516282e-7],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002865933,"about_ca_system_score_gemma":0.00623754,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006950869,"about_ca_topic_score_gemma":0.0002007814,"domain_scores_codex":[0.9960459,0.0007428615,0.002449487,0.0003410882,0.0001820427,0.0002386272],"domain_scores_gemma":[0.9901865,0.001984933,0.007407505,0.0001274048,0.0001178387,0.0001757927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009647159,0.0002525919,0.002056808,0.0008745047,0.0002032967,0.0001857838,0.00001471388,0.00005223734,0.0000599544,0.000008285755,0.0003515822,0.9958438],"study_design_scores_gemma":[0.0007625229,0.001137563,0.0003690965,0.001136836,0.00063269,0.0005789541,0.00003457665,0.0000946093,0.000003359963,0.0000211798,0.9950229,0.000205737],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0399215,0.9570688,0.00001492972,0.00004320622,0.002551877,0.0002188615,0.00002584861,0.000001186955,0.0001537795],"genre_scores_gemma":[0.002552152,0.9941747,0.0008093024,0.0001064317,0.002292525,0.00001563078,0.00001258516,0.00003343496,0.000003294307],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.995638,"threshold_uncertainty_score":0.9993961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2898120336780495,"score_gpt":0.5445730461990795,"score_spread":0.25476101252103,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}