{"id":"W4285493158","doi":"10.1126/sciimmunol.abn8097","title":"Local delivery of low-dose anti–CTLA-4 to the melanoma lymphatic basin leads to systemic T <sub>reg</sub> reduction and effector T cell activation","year":2022,"lang":"en","type":"article","venue":"Science Immunology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Medicine; Melanoma; Immunology; Blockade; Lymphatic system; T cell; Sentinel lymph node; CTLA-4; Immune system; Cancer research; Internal medicine; Cancer; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009305,0.0001234603,0.0002425854,0.0003516058,0.000368339,0.00001855459,0.0002659349,0.00004632039,0.00002662034],"category_scores_gemma":[0.0000648901,0.00009554198,0.00005062347,0.001261072,0.0005888705,0.0001284184,0.000171319,0.0001183564,0.00001758186],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004812134,"about_ca_system_score_gemma":0.0004046979,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002663313,"about_ca_topic_score_gemma":0.000004063948,"domain_scores_codex":[0.9985769,0.0001679361,0.0002629652,0.0003604893,0.0003350438,0.0002966708],"domain_scores_gemma":[0.9992635,0.00007849639,0.0001218932,0.0003732916,0.0001045502,0.00005827387],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001304533,0.00006703893,0.000572636,0.00004596724,0.00002094921,0.000002585078,0.001012226,0.0001188292,0.968532,0.00001265925,0.0002408251,0.02806981],"study_design_scores_gemma":[0.001092708,0.001436474,0.04414348,0.00009608654,0.00002414762,0.0003108786,0.001744235,0.0001719792,0.9505506,0.000004662112,0.0003163627,0.0001084369],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952213,0.0009780071,0.0002975471,0.001759183,0.000882344,0.0007715367,0.000005990619,0.00002500373,0.00005911131],"genre_scores_gemma":[0.999218,0.00007849887,0.00003929228,0.000453244,0.00003543116,0.00008847196,0.000004764359,0.00001104378,0.00007120197],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04357085,"threshold_uncertainty_score":0.3896089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007034484885960348,"score_gpt":0.2322368895757887,"score_spread":0.2252024046898284,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}