{"id":"W4285494058","doi":"10.1038/s41598-022-16175-6","title":"Mouse oocytes carrying metacentric Robertsonian chromosomes have fewer crossover sites and higher aneuploidy rates than oocytes carrying acrocentric chromosomes alone","year":2022,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Prenatal Screening and Diagnostics","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"Synapsis; Aneuploidy; Homologous chromosome; Meiosis; Biology; Centromere; Chromosome; Genetics; Synaptonemal complex; Prophase; Telomere; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001117105,0.0005488858,0.0008777452,0.0006022312,0.001991118,0.0008129771,0.0002665234,0.0001451868,0.0009881404],"category_scores_gemma":[0.0007642792,0.000489347,0.0002773123,0.00136881,0.0005145508,0.0005117476,0.0007943535,0.0005617001,0.0000198056],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003476049,"about_ca_system_score_gemma":0.000322938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005120838,"about_ca_topic_score_gemma":0.00005793756,"domain_scores_codex":[0.9946285,0.0001397348,0.000889888,0.001667635,0.001525879,0.001148365],"domain_scores_gemma":[0.9969897,0.0003482884,0.0005746754,0.001173185,0.0003049809,0.0006091205],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003171291,0.0006634701,0.8385655,0.0003529769,0.0006426174,0.01190377,0.002616099,0.0007224769,0.1206622,0.00005621012,0.02145833,0.002039188],"study_design_scores_gemma":[0.005986137,0.0008282795,0.2156927,0.0004315265,0.002154507,0.01213202,0.00289878,0.002691129,0.6783531,0.0009211762,0.07524224,0.002668418],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9784369,0.01635247,0.00001461483,0.0004725827,0.002806619,0.0008188114,0.0000893262,0.000342764,0.0006659317],"genre_scores_gemma":[0.983292,0.0001570169,0.0004766787,0.000197559,0.0002603607,0.0001111722,0.0005298986,0.00009362062,0.01488174],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6228729,"threshold_uncertainty_score":0.9999251,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01997545888992154,"score_gpt":0.2664041332637529,"score_spread":0.2464286743738314,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}