{"id":"W4285495463","doi":"10.1038/s41522-022-00320-0","title":"In silico identification of two peptides with antibacterial activity against multidrug-resistant Staphylococcus aureus","year":2022,"lang":"en","type":"article","venue":"npj Biofilms and Microbiomes","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"St. George's, University of London; Biotechnology and Biological Sciences Research Council; Research Councils UK; Life Sciences Research Network Wales; Fundação de Amparo à Pesquisa do Estado de Minas Gerais; Institute of Infection and Immunity; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"In silico; Staphylococcus aureus; Microbiology; Antimicrobial peptides; Antimicrobial; Biology; Pathogen; Bacterial cell structure; Multiple drug resistance; Human pathogen; Bacteria; In vivo; Biofilm; In vitro; Computational biology; Antibiotics; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002756029,0.0002559354,0.0004415079,0.0002979989,0.0003295801,0.00003574197,0.0002052729,0.00009713725,0.0001798585],"category_scores_gemma":[0.000009305008,0.0002241341,0.00008644359,0.0002812398,0.0004805932,0.0002255155,0.0002155719,0.000274676,0.000009366409],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000580277,"about_ca_system_score_gemma":0.0000781979,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00091585,"about_ca_topic_score_gemma":0.0001982102,"domain_scores_codex":[0.9985698,0.0001764571,0.0003858877,0.000442195,0.00004692552,0.0003787046],"domain_scores_gemma":[0.999276,0.00006396545,0.0003240211,0.0002686662,0.00004547628,0.00002182731],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007318581,0.000404325,0.002219,0.00005578869,0.0001007594,0.00001016625,0.0005543637,0.0000250382,0.9931175,0.000155545,0.0009442382,0.001681441],"study_design_scores_gemma":[0.002347248,0.0002707065,0.01048427,0.00003342766,0.00003098213,0.0000200419,0.001135402,0.000005828122,0.9794319,0.00001529078,0.005921459,0.0003034357],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974942,0.0005686734,0.00001279757,0.0001727557,0.0003760028,0.00036704,0.0008829633,0.00003467961,0.00009085529],"genre_scores_gemma":[0.9981576,0.0001078866,0.0001162243,0.00008057374,0.00002630356,0.00002916405,0.0001835304,0.00002474303,0.001274],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01368557,"threshold_uncertainty_score":0.9139925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007180625437411194,"score_gpt":0.2250825338184737,"score_spread":0.2179019083810625,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}