{"id":"W4285498294","doi":"10.1016/j.clml.2022.07.004","title":"Real-World Persistence and Time to Next Treatment With Ibrutinib in Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Including Patients at High Risk for Atrial Fibrillation or Stroke","year":2022,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Group for Research in Decision Analysis","funders":"Janssen Scientific Affairs; AbbVie; Merck","keywords":"Ibrutinib; Medicine; Chronic lymphocytic leukemia; Internal medicine; Discontinuation; Stroke (engine); Atrial fibrillation; Lower risk; Oncology; Leukemia; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000932079,0.0001398353,0.0003028296,0.0004780864,0.0003376999,0.0009511948,0.0002073087,0.0003968933,0.001294558],"category_scores_gemma":[0.003809287,0.0001076425,0.0003587975,0.0008523494,0.0001428158,0.0005555475,0.0003328165,0.0005590069,0.0002118506],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004055348,"about_ca_system_score_gemma":0.0002995566,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001805159,"about_ca_topic_score_gemma":0.003387788,"domain_scores_codex":[0.99932,0.0001967521,0.0001292134,0.0001439237,0.00009186906,0.0001182603],"domain_scores_gemma":[0.995889,0.0007476386,0.00249985,0.0001372533,0.0002005296,0.0005257255],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003584971,0.00002417915,0.9968202,0.000009694151,0.00003795334,0.00005651828,0.00003795956,0.00004990918,0.00006861905,0.00000842976,0.00009909709,0.002428958],"study_design_scores_gemma":[0.00002612463,0.0002789204,0.9979331,0.000014232,0.00004603712,0.0005250258,0.0002158499,0.0004536171,0.00006838302,0.00004867852,0.000382282,0.000007820262],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984245,0.0005866815,0.0000622666,0.0001173772,0.000006241128,0.000005122485,0.0003589643,0.000003422211,0.0004355057],"genre_scores_gemma":[0.9992896,0.0001245245,0.00005062926,0.00003917676,0.00001612228,0.000005599337,0.0004215584,0.000001179538,0.00005155442],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001805159,"threshold_uncertainty_score":0.004929364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04458121361638287,"score_gpt":0.3073229471894323,"score_spread":0.2627417335730494,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}