{"id":"W4285500008","doi":"10.1016/j.ijrobp.2022.06.098","title":"No Association Between Polygenic Risk Scores for Cancer and Development of Radiation Therapy Toxicity","year":2022,"lang":"en","type":"article","venue":"International Journal of Radiation Oncology*Biology*Physics","topic":"Effects of Radiation Exposure","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Cancer Institute; Cancer Research UK; National Institutes of Health; European Regional Development Fund; Manchester Biomedical Research Centre; European Commission; Instituto de Salud Carlos III; National Institute for Health and Care Research","keywords":"Medicine; Breast cancer; Prostate cancer; Odds ratio; Radiogenomics; Internal medicine; Oncology; Lung cancer; Confidence interval; Toxicity; Single-nucleotide polymorphism; Cancer; Genotype; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005380996,0.0004477002,0.0003240933,0.0005900279,0.0003155503,0.0007360069,0.0004472856,0.0005995375,0.00295553],"category_scores_gemma":[0.01021564,0.0002332759,0.001877211,0.0006443436,0.0006236691,0.0004629437,0.0006058805,0.0007048845,0.0002149738],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002640971,"about_ca_system_score_gemma":0.0005004816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003681267,"about_ca_topic_score_gemma":0.003901761,"domain_scores_codex":[0.9970528,0.001688469,0.0001771654,0.0006176572,0.0002505718,0.0002132983],"domain_scores_gemma":[0.9890849,0.005378678,0.00271133,0.001866545,0.0003504163,0.0006081066],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004652829,0.00002135607,0.9948149,0.00001400602,0.0006417738,0.00005423015,0.00002463208,0.0002631301,0.0005429137,0.0001067452,0.0001422919,0.002908592],"study_design_scores_gemma":[0.00004082864,0.0003314352,0.995131,0.000007788151,0.000452699,0.0003470911,0.00003269233,0.00262644,0.000271972,0.0004255862,0.0003225801,0.00000990303],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942484,0.0006918442,0.002764775,0.0003816766,0.00003116718,0.00002295622,0.0007304293,0.00003457653,0.001094116],"genre_scores_gemma":[0.9991719,0.00003922871,0.0003429023,0.00007645164,0.0000216873,0.000005698098,0.0002306221,0.000005398901,0.0001061898],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005380996,"threshold_uncertainty_score":0.02845782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02107180137093647,"score_gpt":0.3377260094710199,"score_spread":0.3166542081000834,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}