{"id":"W4285587978","doi":"10.1111/epi.17367","title":"A phase 2, randomized, double‐blind, placebo‐controlled study to evaluate the efficacy and safety of soticlestat as adjunctive therapy in pediatric patients with Dravet syndrome or Lennox–Gastaut syndrome (<scp>ELEKTRA</scp>)","year":2022,"lang":"en","type":"article","venue":"Epilepsia","topic":"Epilepsy research and treatment","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Takeda Pharmaceuticals U.S.A.","keywords":"Placebo; Dravet syndrome; Lennox–Gastaut syndrome; Medicine; Clinical endpoint; Population; Adverse effect; Adjunctive treatment; Incidence (geometry); Randomized controlled trial; Anesthesia; Pediatrics; Epilepsy; Internal medicine; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00169631,0.001431228,0.0024466,0.0004112124,0.0003721169,0.0006954395,0.0007784794,0.001585016,0.006736756],"category_scores_gemma":[0.001552277,0.0007622873,0.001178817,0.0003468027,0.0008438231,0.0009743181,0.0002902989,0.0020039,0.0008153042],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004211609,"about_ca_system_score_gemma":0.001303412,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004485569,"about_ca_topic_score_gemma":0.001379009,"domain_scores_codex":[0.9994936,0.0002462927,0.00003990791,0.0001115241,0.00004877115,0.00005993013],"domain_scores_gemma":[0.9991353,0.0002488955,0.0002326202,0.00007103222,0.00009298418,0.000219088],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9551041,0.01813848,0.001015359,0.001223399,0.00115722,0.00007416357,0.00008426882,0.0002614987,0.00663347,0.000169321,0.0008499679,0.01528879],"study_design_scores_gemma":[0.9466876,0.05119868,0.001033272,0.00002317905,0.0002177997,0.00003142035,0.00001251067,0.0001549816,0.0002634751,0.00004754408,0.0003234051,0.000006220081],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.97982,0.004102878,0.001133218,0.0004975694,0.0004767156,0.01039345,0.001375097,0.0001483697,0.002052658],"genre_scores_gemma":[0.9715033,0.003593763,0.003467301,0.00149582,0.0004430138,0.01526194,0.001408705,0.00002975597,0.002796427],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006736756,"threshold_uncertainty_score":0.0225367,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02417149308038372,"score_gpt":0.3209450584843908,"score_spread":0.296773565404007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}