{"id":"W4285587978","doi":"10.1111/epi.17367","title":"A phase 2, randomized, double‐blind, placebo‐controlled study to evaluate the efficacy and safety of soticlestat as adjunctive therapy in pediatric patients with Dravet syndrome or Lennox–Gastaut syndrome (<scp>ELEKTRA</scp>)","year":2022,"lang":"en","type":"article","venue":"Epilepsia","topic":"Epilepsy research and treatment","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Takeda Pharmaceuticals U.S.A.","keywords":"Placebo; Dravet syndrome; Lennox–Gastaut syndrome; Medicine; Clinical endpoint; Population; Adverse effect; Adjunctive treatment; Incidence (geometry); Randomized controlled trial; Anesthesia; Pediatrics; Epilepsy; Internal medicine; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.003245436,0.0005005063,0.001926472,0.0006254892,0.0003386645,0.0000490922,0.0003024836,0.00005366735,0.0002599504],"category_scores_gemma":[0.0007391491,0.0002655365,0.0002080568,0.001094923,0.0001941989,0.000125914,0.0002251284,0.0006361314,0.00003013689],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002486187,"about_ca_system_score_gemma":0.0005676135,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002761066,"about_ca_topic_score_gemma":0.00008501791,"domain_scores_codex":[0.9941494,0.00172619,0.0009617311,0.0007623642,0.001641404,0.0007589377],"domain_scores_gemma":[0.9949504,0.003387918,0.0002806512,0.0006816271,0.0002606037,0.0004388512],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8750382,0.01587714,0.09794953,0.00004331725,0.001569502,0.001339185,0.00680132,0.0001988985,0.00000975325,0.0000336754,0.00009368078,0.001045794],"study_design_scores_gemma":[0.7580475,0.04259143,0.1962388,0.00004290709,0.0007237542,0.0001698149,0.001846363,0.0001374855,0.00001207373,0.00004347049,0.00002419147,0.0001222952],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9732451,0.0005431256,0.00001872507,0.0003406934,0.0000948441,0.02535884,0.00008232413,0.00004476707,0.0002715291],"genre_scores_gemma":[0.995442,0.0002588309,0.00007658463,0.00015702,0.00003162708,0.003335367,0.00007680003,0.00007164888,0.0005500636],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1169908,"threshold_uncertainty_score":0.9999797,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02417149308038372,"score_gpt":0.3209450584843908,"score_spread":0.296773565404007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}