{"id":"W4285590406","doi":"10.1101/2022.07.15.500247","title":"Intralumenal docking of Cx36 channels in the ER isolates mis-trafficked protein","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft; National Institutes of Health; McGovern Medical School; European Commission; University of Texas Health Science Center at Houston","keywords":"Docking (animal); Computer science; Medicine; Veterinary medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001582371,0.0002078336,0.0002406995,0.0002105463,0.0002844059,0.0004312605,0.0002484804,0.0004070355,0.001241782],"category_scores_gemma":[0.0001506181,0.0001331579,0.000202993,0.000140112,0.0003080901,0.0003506192,0.0003527458,0.0004551065,0.001066114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005457797,"about_ca_system_score_gemma":0.0002134495,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007132904,"about_ca_topic_score_gemma":0.0006205696,"domain_scores_codex":[0.9998885,0.00001397796,0.000008095115,0.00003100157,0.0000356911,0.00002271648],"domain_scores_gemma":[0.9998757,0.0000195591,0.00003269839,0.00002955666,0.00001704212,0.00002547054],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001032487,0.00001207332,0.0002536215,0.00001684562,0.000003643803,0.0002233525,0.00002158236,0.0001885815,0.9979948,0.0005559592,0.00006216951,0.0005641006],"study_design_scores_gemma":[0.00001206891,0.00004489317,0.003256189,0.000005325065,0.000006428709,0.0005241258,0.00005140944,0.002908639,0.9906616,0.000192039,0.002331861,0.000005578593],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925983,0.0003917193,0.004982258,0.0001493106,0.00004281473,0.000008789617,0.0001882157,0.00009727452,0.001541219],"genre_scores_gemma":[0.9910184,0.0002089571,0.003240221,0.00004051823,0.000007450236,0.000008351112,0.0002752445,0.00005325279,0.005147635],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001241782,"threshold_uncertainty_score":0.004154146,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01119624791938626,"score_gpt":0.2224833639800587,"score_spread":0.2112871160606724,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}