{"id":"W4285596384","doi":"10.3390/ph15070870","title":"Clinical Impact of Functional CYP2C19 and CYP2D6 Gene Variants on Treatment with Antidepressants in Young People with Depression: A Danish Cohort Study","year":2022,"lang":"en","type":"article","venue":"Pharmaceuticals","topic":"Treatment of Major Depression","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"Novo Nordisk Fonden; Alfred Benzon Foundation; Lundbeckfonden","keywords":"CYP2C19; CYP2D6; Depression (economics); Danish; Medicine; Cohort; Psychiatry; Cohort study; Internal medicine; Bioinformatics; Pharmacology; Oncology; Biology; Cytochrome P450","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001482604,0.0003068744,0.0006395149,0.0008007837,0.0006694573,0.0007609585,0.0005202137,0.0003968509,0.0009459948],"category_scores_gemma":[0.002064921,0.0005433953,0.001375217,0.001370395,0.0002941691,0.0002541232,0.0006153994,0.0004425915,0.0001811588],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009161172,"about_ca_system_score_gemma":0.000889915,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.07421104,"about_ca_topic_score_gemma":0.07842709,"domain_scores_codex":[0.9986052,0.0002872349,0.0002183014,0.0004375501,0.0002737925,0.0001778692],"domain_scores_gemma":[0.9985995,0.0001995067,0.0005028338,0.0002582361,0.0002474026,0.0001925519],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001420152,0.00001792335,0.9978927,0.00003203329,0.0002778641,0.0001702491,0.0001441145,0.00006764323,0.0002314053,0.00003194073,0.0001714891,0.0008206044],"study_design_scores_gemma":[0.00001768655,0.00003658049,0.9988433,0.00001431848,0.0001485906,0.000224982,0.0001220284,0.0001231937,0.00005405684,0.00001150966,0.0003977182,0.000006090751],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956417,0.0009163746,0.000268139,0.00003652927,0.00001346316,0.00002485719,0.002693591,0.000003363426,0.0004019659],"genre_scores_gemma":[0.9972186,0.0005259311,0.0002820833,0.00002480403,0.000005739805,0.00001884087,0.001653147,0.000003060155,0.0002678701],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07421104,"threshold_uncertainty_score":0.1475582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06306137035590093,"score_gpt":0.4101138579758822,"score_spread":0.3470524876199813,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}