{"id":"W4285596414","doi":"10.51731/cjht.2022.392","title":"Trace Amine-Associated Receptor 1 Agonists for Schizophrenia","year":2022,"lang":"en","type":"article","venue":"Canadian Journal of Health Technologies","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Antipsychotic; Medicine; Partial agonist; Agonist; Pharmacology; Clinical trial; Dopamine receptor D2; Schizophrenia (object-oriented programming); Internal medicine; Psychiatry; Dopamine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005638419,0.0004545717,0.0005253074,0.0004358418,0.0002807991,0.0003388079,0.0003041119,0.0005445026,0.01351903],"category_scores_gemma":[0.0004885198,0.00007352344,0.0006427226,0.0002505725,0.0002228411,0.000235795,0.000378689,0.001349932,0.003367405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008587545,"about_ca_system_score_gemma":0.001364196,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002361278,"about_ca_topic_score_gemma":0.008289987,"domain_scores_codex":[0.9998337,0.00004794034,0.00001950653,0.00001495943,0.00005800488,0.00002582761],"domain_scores_gemma":[0.9997503,0.00004017519,0.00006561513,0.00001038961,0.00005970948,0.00007369931],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003111552,0.0004991648,0.001052496,0.003194584,0.0001682805,0.001189827,0.00009734081,0.0001726417,0.02448934,0.005084435,0.09203572,0.8689047],"study_design_scores_gemma":[0.004680033,0.006808531,0.01975103,0.003237143,0.0004583855,0.006047669,0.0001648533,0.0006283236,0.00658911,0.008360608,0.9431838,0.00009057646],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.05796858,0.7736517,0.005034036,0.05159727,0.006683486,0.0005547173,0.002044186,0.0008446788,0.1016214],"genre_scores_gemma":[0.296288,0.5881969,0.01119987,0.0247583,0.003262131,0.0005596693,0.002560612,0.0001042968,0.07307016],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01351903,"threshold_uncertainty_score":0.04522562,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01674535363351529,"score_gpt":0.2506839181679237,"score_spread":0.2339385645344084,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}