{"id":"W4285600016","doi":"10.1053/j.gastro.2022.07.004","title":"Altered Gut Microbiome Composition and Function Are Associated With Gut Barrier Dysfunction in Healthy Relatives of Patients With Crohn’s Disease","year":2022,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":194,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sinai Health System; University of Manitoba; University of Ottawa; Hôpital Maisonneuve-Rosemont; McMaster University; Mount Sinai Hospital; University of Calgary; Children's Hospital of Eastern Ontario; Population Health Research Institute; University of Alberta; University of British Columbia; Hospital for Sick Children; Public Health Ontario; BC Children's Hospital; SickKids Foundation; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Ferring Pharmaceuticals; Canadian Association of Gastroenterology; Crohn's and Colitis Foundation of Canada; Crohn's and Colitis Canada; Canadian Institutes of Health Research; Leona M. and Harry B. Helmsley Charitable Trust","keywords":"Gut microbiome; Microbiome; Disease; Crohn's disease; Gut flora; Barrier function; Function (biology); Medicine; Composition (language); Intestinal Microbiome; Immunology; Physiology; Internal medicine; Bioinformatics; Biology; Genetics; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001072348,0.0001324206,0.0001893978,0.0001121805,0.0001271417,0.000004978288,0.00005471922,0.00005342778,0.00002647981],"category_scores_gemma":[0.00000787006,0.0001211592,0.00002552776,0.00008345195,0.0001070438,0.000007710881,0.00007561976,0.0001457218,3.890101e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006649033,"about_ca_system_score_gemma":0.00004811851,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002038441,"about_ca_topic_score_gemma":0.0002509021,"domain_scores_codex":[0.9988525,0.0002640329,0.0002145083,0.0003299063,0.00008007335,0.0002589855],"domain_scores_gemma":[0.9994438,0.000006616792,0.0002450368,0.0001467926,0.00007270167,0.00008504143],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01934013,0.0003645323,0.9093103,0.00003099106,0.00006151649,0.000004179002,0.00007048448,0.0001779824,0.07034498,0.000003118357,0.0002544928,0.00003729144],"study_design_scores_gemma":[0.004400874,0.004801275,0.9903216,0.00002052914,0.00003191515,0.000006260389,0.00007928426,0.00001453614,0.00006219206,0.000005483283,0.0001828575,0.00007320165],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985902,0.00007680838,0.0003167554,0.0002520704,0.0001049753,0.00033205,0.0003144112,0.000007242309,0.00000554438],"genre_scores_gemma":[0.9975492,0.00001053791,0.00006082553,0.0007066538,0.00001999398,0.0000414569,0.001567178,0.0000166336,0.00002752151],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08101129,"threshold_uncertainty_score":0.4940728,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004775925947904583,"score_gpt":0.1999132823755617,"score_spread":0.1951373564276571,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}