{"id":"W4285600016","doi":"10.1053/j.gastro.2022.07.004","title":"Altered Gut Microbiome Composition and Function Are Associated With Gut Barrier Dysfunction in Healthy Relatives of Patients With Crohn’s Disease","year":2022,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":194,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sinai Health System; University of Manitoba; University of Ottawa; Hôpital Maisonneuve-Rosemont; McMaster University; Mount Sinai Hospital; University of Calgary; Children's Hospital of Eastern Ontario; Population Health Research Institute; University of Alberta; University of British Columbia; Hospital for Sick Children; Public Health Ontario; BC Children's Hospital; SickKids Foundation; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Ferring Pharmaceuticals; Canadian Association of Gastroenterology; Crohn's and Colitis Foundation of Canada; Crohn's and Colitis Canada; Canadian Institutes of Health Research; Leona M. and Harry B. Helmsley Charitable Trust","keywords":"Gut microbiome; Microbiome; Disease; Crohn's disease; Gut flora; Barrier function; Function (biology); Medicine; Composition (language); Intestinal Microbiome; Immunology; Physiology; Internal medicine; Bioinformatics; Biology; Genetics; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002300494,0.0006010712,0.0007415896,0.001072909,0.001092945,0.0006446228,0.0003314932,0.0007515477,0.002718044],"category_scores_gemma":[0.002506827,0.0003692463,0.000451777,0.0009901159,0.0004000823,0.0004748178,0.0004439667,0.000630824,0.0003207028],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002552645,"about_ca_system_score_gemma":0.0001908381,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002943195,"about_ca_topic_score_gemma":0.001958563,"domain_scores_codex":[0.9996578,0.00009991553,0.00004222394,0.000087315,0.00004575229,0.00006711831],"domain_scores_gemma":[0.9992436,0.0001766292,0.0002891227,0.00005226709,0.0000626361,0.0001757333],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001110263,0.0001670827,0.9852308,0.00005147302,0.000150228,0.00494528,0.0006344058,0.00008588573,0.004026419,0.00007097947,0.0002547979,0.003272303],"study_design_scores_gemma":[0.00001873765,0.0003080162,0.9909447,0.0000188243,0.0001236206,0.006692041,0.0008853761,0.0001893464,0.0003473283,0.0001674313,0.0002896167,0.00001491723],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990074,0.0003744025,0.0000583255,0.00007769169,0.00001660556,0.000002246354,0.00008420076,0.000005297959,0.0003737867],"genre_scores_gemma":[0.9995703,0.0001085754,0.00006237339,0.00003696177,0.00001576762,0.000002218479,0.0000653665,0.000002478919,0.0001359686],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002943195,"threshold_uncertainty_score":0.009092748,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004775925947904583,"score_gpt":0.1999132823755617,"score_spread":0.1951373564276571,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}