{"id":"W4285601140","doi":"10.1016/j.biopsych.2022.06.036","title":"Additive Effects of Stress and Alcohol Exposure on Accelerated Epigenetic Aging in Alcohol Use Disorder","year":2022,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"David Geffen School of Medicine, University of California, Los Angeles; Janssen Pharmaceuticals; Medical Research Council; Chief Scientist Office, Scottish Government Health and Social Care Directorate; School of Medicine, Emory University; University of California, Los Angeles; Institute of Genetics; National Institutes of Health; National Institute on Alcohol Abuse and Alcoholism; Emory University; Sackler Trust; Wellcome Trust; University of Edinburgh; National Institute of Mental Health; Pfizer; National Alliance for Research on Schizophrenia and Depression; Eli Lilly and Company; Scottish Funding Council; Virginia Marine Resources Commission; Brain and Behavior Research Foundation","keywords":"Epigenetics; Alcohol use disorder; DNA methylation; Medicine; Methylation; Alcohol; Alcohol consumption; Internal medicine; Psychology; Clinical psychology; Genetics; Biology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001319855,0.000162935,0.00018067,0.00006796761,0.00009138237,0.00001281672,0.0001307379,0.0001374228,0.00003907319],"category_scores_gemma":[0.0001011698,0.0001398518,0.00006244644,0.0001459567,0.00007120937,0.000002916211,0.000130962,0.0001643678,8.774305e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008551767,"about_ca_system_score_gemma":0.00003062766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003625494,"about_ca_topic_score_gemma":0.00005267811,"domain_scores_codex":[0.9987533,0.0002714737,0.0002427432,0.000414926,0.0001099665,0.0002075583],"domain_scores_gemma":[0.9995169,0.00007932066,0.0001086812,0.0002100193,0.00002893954,0.00005610793],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001902243,0.0003558187,0.8778762,0.00003279928,0.00003807505,0.000003814967,0.00003059363,0.0008291938,0.1132751,0.0001163569,0.00005380919,0.007197975],"study_design_scores_gemma":[0.001257954,0.001737589,0.9498194,0.00002848469,0.00001013422,9.939532e-7,0.0001050879,0.00004288326,0.04513414,0.0003382745,0.001309128,0.0002159528],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935523,0.005422988,0.00008112951,0.0000957329,0.0002902032,0.0003341924,0.0001064184,0.000008286684,0.0001087441],"genre_scores_gemma":[0.9981468,0.000834475,0.0003377537,0.0002151952,0.00008183551,0.00005314418,0.0002838527,0.00001217633,0.00003482304],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07194318,"threshold_uncertainty_score":0.5702991,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02509874967853812,"score_gpt":0.2825822355264697,"score_spread":0.2574834858479316,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}