{"id":"W4285601140","doi":"10.1016/j.biopsych.2022.06.036","title":"Additive Effects of Stress and Alcohol Exposure on Accelerated Epigenetic Aging in Alcohol Use Disorder","year":2022,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"David Geffen School of Medicine, University of California, Los Angeles; Janssen Pharmaceuticals; Medical Research Council; Chief Scientist Office, Scottish Government Health and Social Care Directorate; School of Medicine, Emory University; University of California, Los Angeles; Institute of Genetics; National Institutes of Health; National Institute on Alcohol Abuse and Alcoholism; Emory University; Sackler Trust; Wellcome Trust; University of Edinburgh; National Institute of Mental Health; Pfizer; National Alliance for Research on Schizophrenia and Depression; Eli Lilly and Company; Scottish Funding Council; Virginia Marine Resources Commission; Brain and Behavior Research Foundation","keywords":"Epigenetics; Alcohol use disorder; DNA methylation; Medicine; Methylation; Alcohol; Alcohol consumption; Internal medicine; Psychology; Clinical psychology; Genetics; Biology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003072869,0.0004256654,0.0004721626,0.0003836071,0.0002331779,0.0003852695,0.0002004824,0.000233336,0.002400335],"category_scores_gemma":[0.0006559691,0.0003002509,0.0003467713,0.0001979865,0.0002405417,0.0001960835,0.0006621378,0.0004003164,0.0001165713],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002505926,"about_ca_system_score_gemma":0.0003473074,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001894298,"about_ca_topic_score_gemma":0.004407386,"domain_scores_codex":[0.9997475,0.0001027018,0.00001746223,0.00004769452,0.000041379,0.00004324225],"domain_scores_gemma":[0.9995152,0.0001186901,0.00007507985,0.00006976003,0.00004283898,0.00017846],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.03577955,0.0008362894,0.2363614,0.0001899784,0.001605494,0.0007050757,0.0003369513,0.001080232,0.6821429,0.001009534,0.0003825961,0.03957001],"study_design_scores_gemma":[0.00005223108,0.001635221,0.9798992,0.00001177136,0.0005415629,0.0002965511,0.0001966308,0.0005237052,0.0159105,0.0005185129,0.000396101,0.00001804005],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982117,0.0008317478,0.0002926457,0.00006377347,0.00002129145,0.000003980622,0.0001201679,0.00001214914,0.0004425904],"genre_scores_gemma":[0.9984457,0.0003713274,0.000318676,0.00003489538,0.0000151361,0.000005879797,0.00006906591,0.000005959406,0.000733472],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002400335,"threshold_uncertainty_score":0.008029938,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02509874967853812,"score_gpt":0.2825822355264697,"score_spread":0.2574834858479316,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}