{"id":"W4285605340","doi":"10.1016/j.bpj.2022.07.015","title":"Multisite phosphorylation and binding alter conformational dynamics of the 4E-BP2 protein","year":2022,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Dynamics (music); Phosphorylation; Biophysics; Chemistry; Cell biology; Biology; Biochemistry; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001387419,0.00005672406,0.00006347676,0.00001658264,0.0002438059,0.00002101033,0.00009979735,0.00002698362,0.00007311828],"category_scores_gemma":[0.00001252509,0.00004149085,0.00006809086,0.00004861458,0.00003291111,0.00000524869,0.0001188499,0.0001376178,7.00429e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002012159,"about_ca_system_score_gemma":0.00002321724,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003515146,"about_ca_topic_score_gemma":8.15794e-7,"domain_scores_codex":[0.999464,0.00004851788,0.0001456207,0.00007524621,0.000180474,0.0000861423],"domain_scores_gemma":[0.9997268,0.000004572631,0.0001298196,0.00006543485,0.0000394092,0.00003394703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003291096,0.00002257029,0.0002378598,0.00000366648,0.00001526118,3.755709e-7,0.00003448013,0.0001748756,0.9966186,0.001323428,0.00004046918,0.001495453],"study_design_scores_gemma":[0.0003743017,0.0001762973,0.0007475193,0.00001012751,0.000008651728,0.00004775111,0.0001516677,0.007708424,0.9893112,0.0002816408,0.001096305,0.00008610192],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966226,0.00002291748,0.002909803,0.0001477683,0.0001269735,0.00009071813,0.00002614791,0.000001467103,0.00005161705],"genre_scores_gemma":[0.9992157,0.000005720544,0.000419596,0.00005006209,0.0001177344,0.000005801966,0.00002501282,0.000005926394,0.0001544262],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007533549,"threshold_uncertainty_score":0.1875182,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006042615044821924,"score_gpt":0.2151503459636908,"score_spread":0.2091077309188688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}