{"id":"W4285606562","doi":"10.1016/j.ijrobp.2022.07.001","title":"Final Safety and Health-Related Quality of LIfe Results of the Phase 2/3 Act.In.Sarc Study With Preoperative NBTXR3 Plus Radiation Therapy Versus Radiation Therapy in Locally Advanced Soft-Tissue Sarcoma","year":2022,"lang":"en","type":"article","venue":"International Journal of Radiation Oncology*Biology*Physics","topic":"Sarcoma Diagnosis and Treatment","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eisai; Clovis Oncology; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Medicine; Adverse effect; Trunk; Radiation therapy; Quality of life (healthcare); Population; Surgery; Soft tissue sarcoma; External beam radiation; Sarcoma; Soft tissue; Incidence (geometry); Nuclear medicine; Internal medicine; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001720505,0.0002134094,0.0008284629,0.0002413546,0.0001058604,0.00000946476,0.0002563165,0.00009935195,0.00003041761],"category_scores_gemma":[0.0003390661,0.0001548938,0.0001213261,0.0004161813,0.0001602011,0.0002043316,0.00005258363,0.0004959716,4.359205e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001562304,"about_ca_system_score_gemma":0.001545887,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004892908,"about_ca_topic_score_gemma":0.0001709826,"domain_scores_codex":[0.9960557,0.001300661,0.00165302,0.0002866498,0.0005121389,0.0001918886],"domain_scores_gemma":[0.9959064,0.0009819661,0.002412633,0.0002003357,0.0004119285,0.00008677901],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.04696391,0.004666112,0.5506731,0.000005943173,0.0006376181,0.00001907675,0.00538657,0.009080645,0.0004613273,0.0005681752,0.00003460794,0.381503],"study_design_scores_gemma":[0.1423639,0.01802344,0.8349344,0.00004779214,0.00003832408,0.00003023327,0.0009155544,0.001426468,0.0008488451,0.0003111113,0.000932112,0.000127827],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883449,0.003405659,0.0001854417,0.005890613,0.0006092053,0.001376796,0.0001297298,0.000008911784,0.00004873826],"genre_scores_gemma":[0.9963574,0.002664712,0.0002047869,0.0004117483,0.0001444132,0.00006309096,0.0001269162,0.00001912919,0.000007819028],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3813751,"threshold_uncertainty_score":0.6316386,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05669756742817338,"score_gpt":0.3947065547257923,"score_spread":0.3380089872976189,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}