{"id":"W4285702972","doi":"10.21203/rs.2.11143/v3","title":"Crystal structure of DRIK1, a stress-responsive receptor-like pseudokinase, reveals the molecular basis for the absence of ATP binding","year":2020,"lang":"en","type":"preprint","venue":"Research Square","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ministero dello Sviluppo Economico; Universidade Estadual de Campinas; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Ontario Ministry of Economic Development and Innovation; Wellcome Trust; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; Diamond Light Source; Novartis Pharma; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Stress (linguistics); Receptor; Cell biology; Crystal (programming language); Biology; Biophysics; Genetics; Computer science","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000907521,0.0002875803,0.0002821858,0.0001043188,0.000174788,0.0003681775,0.0004528735,0.0003473427,0.001294362],"category_scores_gemma":[0.0001876405,0.0001476388,0.0001886549,0.0001727897,0.0001514626,0.0002096603,0.0001485355,0.0006868024,0.0003856898],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005371443,"about_ca_system_score_gemma":0.0003056857,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001053636,"about_ca_topic_score_gemma":0.0009322207,"domain_scores_codex":[0.9999405,0.000006193238,0.000003264908,0.00001552173,0.00002311162,0.00001137221],"domain_scores_gemma":[0.9999199,0.00001364552,0.00002624391,0.000005468487,0.00001271452,0.00002200264],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003873436,0.00006818965,0.001933603,0.0002466454,0.00003951334,0.0007438012,0.00006784144,0.001447409,0.9900402,0.0006253237,0.0009335351,0.003466553],"study_design_scores_gemma":[0.0003143827,0.0003747406,0.03534517,0.00004963855,0.0001404854,0.004520454,0.0003210416,0.04586839,0.8843268,0.0008237482,0.02785838,0.00005678743],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915773,0.002677936,0.002567766,0.0003293184,0.00005907114,0.0000235704,0.00109563,0.0001945554,0.001474845],"genre_scores_gemma":[0.9892548,0.001249653,0.004327219,0.0001183377,0.00001429046,0.00001848057,0.003284528,0.00003527666,0.001697346],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001294362,"threshold_uncertainty_score":0.004330099,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02678322966765206,"score_gpt":0.3413303280380829,"score_spread":0.3145470983704309,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}