{"id":"W4285726954","doi":"10.1007/s40273-022-01169-z","title":"The Cost Effectiveness of Axicabtagene Ciloleucel Versus Best Supportive Care in the Treatment of Adult Patients with Relapsed or Refractory Large B-Cell Lymphoma (LBCL) After Two or More Lines of Systemic Therapy in Canada","year":2022,"lang":"en","type":"article","venue":"PharmacoEconomics","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Gilead Sciences (Canada); McMaster University","funders":"Gilead Sciences","keywords":"Medicine; Aggressive lymphoma; Cost effectiveness; Quality of life (healthcare); Quality-adjusted life year; Health care; Health economics; Public health; Lymphoma; Health administration; Quality of Life Research; Rituximab; Cost-effectiveness analysis; Intensive care medicine; Oncology; Internal medicine; Risk analysis (engineering); Nursing","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005356215,0.0001727551,0.0004523814,0.0003784951,0.0003363225,0.0009010342,0.0005029691,0.0004495311,0.002236061],"category_scores_gemma":[0.00282848,0.0001003514,0.0007665181,0.0006947549,0.0004347666,0.0003337376,0.0003730409,0.000823985,0.00007977458],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0198029,"about_ca_system_score_gemma":0.01097129,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.5643913,"about_ca_topic_score_gemma":0.7747763,"domain_scores_codex":[0.9993873,0.000236477,0.00004407566,0.00004950274,0.0001174945,0.0001652277],"domain_scores_gemma":[0.9988897,0.000269939,0.0002173999,0.00001829856,0.0001203717,0.0004841692],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.2041537,0.003418468,0.2469201,0.002036227,0.003430583,0.0009608159,0.0004186846,0.02247164,0.002424355,0.002732671,0.0159518,0.495081],"study_design_scores_gemma":[0.02046678,0.02344937,0.9082101,0.0008640126,0.005074887,0.0009042064,0.00160698,0.02432356,0.001178247,0.0008036689,0.01299813,0.0001201419],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9762049,0.01367787,0.0001085443,0.004020956,0.00008954827,0.00009996483,0.001113593,0.00001604581,0.004668661],"genre_scores_gemma":[0.9967067,0.001972671,0.0001250105,0.0003483734,0.00003233444,0.00001368132,0.0003323071,0.000002796476,0.0004662843],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4356087,"threshold_uncertainty_score":0.8763483,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02129219589755746,"score_gpt":0.3223679500872194,"score_spread":0.3010757541896619,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}