{"id":"W4285726954","doi":"10.1007/s40273-022-01169-z","title":"The Cost Effectiveness of Axicabtagene Ciloleucel Versus Best Supportive Care in the Treatment of Adult Patients with Relapsed or Refractory Large B-Cell Lymphoma (LBCL) After Two or More Lines of Systemic Therapy in Canada","year":2022,"lang":"en","type":"article","venue":"PharmacoEconomics","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Gilead Sciences (Canada); McMaster University","funders":"Gilead Sciences","keywords":"Medicine; Aggressive lymphoma; Cost effectiveness; Quality of life (healthcare); Quality-adjusted life year; Health care; Health economics; Public health; Lymphoma; Health administration; Quality of Life Research; Rituximab; Cost-effectiveness analysis; Intensive care medicine; Oncology; Internal medicine; Risk analysis (engineering); Nursing","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003671595,0.0002147432,0.0005444223,0.0001172386,0.00005877973,0.000005132151,0.0002582789,0.00002978644,0.0002477952],"category_scores_gemma":[0.00001835004,0.0001174998,0.00008814367,0.0002470074,0.00008792851,0.00004251345,0.00004480165,0.0001526434,6.080516e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002386184,"about_ca_system_score_gemma":0.002276681,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.1138503,"about_ca_topic_score_gemma":0.2462042,"domain_scores_codex":[0.9980893,0.0004843541,0.0005381157,0.0002674366,0.000312329,0.0003085329],"domain_scores_gemma":[0.9979218,0.001074707,0.0003063721,0.0004102782,0.000221698,0.0000651299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.429844,0.007369753,0.4733086,0.0008528711,0.0007740229,0.0002675995,0.0158907,0.001070905,0.01254473,0.000003782651,0.00006254686,0.05801045],"study_design_scores_gemma":[0.439332,0.03055054,0.1443056,0.0006181967,0.0004837074,0.00003367684,0.09728283,0.001631781,0.2760127,0.000001880884,0.008989558,0.0007574905],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949869,0.001353106,3.936269e-7,0.00003949891,0.0002188756,0.002574574,0.0007131441,0.000003110802,0.0001103998],"genre_scores_gemma":[0.9963356,0.002455884,0.000004420434,0.00007585262,0.00002944531,0.000849508,0.0001047758,0.00003970717,0.0001048283],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.329003,"threshold_uncertainty_score":0.8920507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02129219589755746,"score_gpt":0.3223679500872194,"score_spread":0.3010757541896619,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}