{"id":"W4285727921","doi":"10.1182/bloodadvances.2022007300","title":"Unified gene expression signature of novel <i>NPM1</i> exon 5 mutations in acute myeloid leukemia","year":2022,"lang":"en","type":"article","venue":"Blood Advances","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute for Research in Immunology and Cancer; Hôpital Maisonneuve-Rosemont; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"NPM1; Exon; Myeloid leukemia; Gene; Biology; Mutation; Myeloid; Leukemia; Gene expression; Cancer research; Genetics; Signature (topology); Karyotype; Chromosome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001205525,0.0001583547,0.0001945781,0.0007238524,0.0001884442,0.0004020659,0.0001430263,0.0002597678,0.001014244],"category_scores_gemma":[0.0002303876,0.00007336823,0.0001605449,0.0005553651,0.000187808,0.0001188851,0.0001982555,0.000189752,0.0001907697],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002850537,"about_ca_system_score_gemma":0.0001779871,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000879119,"about_ca_topic_score_gemma":0.001560358,"domain_scores_codex":[0.9998466,0.00001258984,0.00001154014,0.00003969244,0.0000546072,0.00003497128],"domain_scores_gemma":[0.9998986,0.00001600388,0.00004299435,0.000006939637,0.00001796169,0.00001750947],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000663681,0.00003688475,0.09955852,0.00007556599,0.00004986249,0.0008447624,0.00008969892,0.0004431609,0.8841733,0.000304641,0.0005425458,0.01321737],"study_design_scores_gemma":[0.00002802097,0.0002606003,0.8384271,0.00002070622,0.0001566843,0.005450672,0.0003460306,0.004474874,0.1434044,0.0005437135,0.00686719,0.00002006943],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952635,0.0007450961,0.001159221,0.00006311815,0.00001137172,0.00001546414,0.001217491,0.00004694104,0.001477794],"genre_scores_gemma":[0.9964288,0.0002292716,0.001262004,0.00005506287,0.000009402706,0.00001813676,0.001432165,0.000009902686,0.0005553425],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001014244,"threshold_uncertainty_score":0.003392935,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01616325110435443,"score_gpt":0.2900097324574762,"score_spread":0.2738464813531217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}