{"id":"W4285728864","doi":"10.1073/pnas.2122495119","title":"Elevated intracellular Na <sup>+</sup> and osmolarity stimulate catalytic activity of the ubiquitin ligase Nedd4-2","year":2022,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; Cystic Fibrosis Canada","keywords":"Ubiquitin ligase; NEDD4; Intracellular; Ubiquitin; Chemistry; Osmotic concentration; Cell biology; DNA ligase; Molecular biology; Biochemistry; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001735691,0.0003314416,0.0003245763,0.0001299721,0.0001070407,0.000504435,0.0001728922,0.0001733429,0.001231714],"category_scores_gemma":[0.0001109939,0.0001905174,0.0003480218,0.0001047238,0.0002305032,0.0002985456,0.0003545766,0.0003396973,0.0003784717],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003657274,"about_ca_system_score_gemma":0.0001612611,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002337165,"about_ca_topic_score_gemma":0.0003445224,"domain_scores_codex":[0.9998429,0.00002043139,0.00002473262,0.00003493698,0.00003922059,0.00003770131],"domain_scores_gemma":[0.9999166,0.000009284613,0.00002805414,0.00001215419,0.00001221646,0.00002182035],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002147384,0.00001380038,0.0004426273,0.00003493643,0.000007042942,0.00006357719,0.000005191243,0.00004873916,0.9981962,0.00009837312,0.00003546174,0.0008393125],"study_design_scores_gemma":[0.00001283283,0.00007845036,0.005388751,0.000002733253,0.000008430485,0.0002153295,0.00001745343,0.001261141,0.9909607,0.0000663822,0.001983853,0.000003935482],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919416,0.001575938,0.004537341,0.0001160476,0.00004180634,0.00002574698,0.0004438661,0.00008337512,0.001234209],"genre_scores_gemma":[0.9927792,0.0005143958,0.003434065,0.00006182957,0.000009209886,0.00002686629,0.0007746941,0.00002415552,0.002375648],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001231714,"threshold_uncertainty_score":0.004120469,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02449505152855612,"score_gpt":0.270913606321088,"score_spread":0.2464185547925318,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}