{"id":"W4285730617","doi":"10.1002/wsbm.1578","title":"Direct regulation of TCR rearrangement and expression by E proteins during early T cell development","year":2022,"lang":"en","type":"review","venue":"WIREs Mechanisms of Disease","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Hospital; University of Toronto; Sunnybrook Health Science Centre","funders":"Institute of Infection and Immunity; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Division of Intramural Research, National Institute of Allergy and Infectious Diseases","keywords":"T-cell receptor; Biology; Chromatin; T cell; Cell biology; Epigenetics; Recombinase; Genetics; V(D)J recombination; Genome instability; Recombination-activating gene; Allelic exclusion; Regulation of gene expression; Jurkat cells; Gene; Immune system; DNA; DNA damage","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002015733,0.0003862348,0.001056168,0.0002092596,0.0002183482,0.000007507632,0.0003201934,0.0002736839,0.0009682639],"category_scores_gemma":[0.00002547049,0.0003316903,0.0002261173,0.0001011136,0.0001161112,0.00005852495,0.000442223,0.0002455217,0.0000277695],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007006194,"about_ca_system_score_gemma":0.0001889373,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002436615,"about_ca_topic_score_gemma":0.000001463125,"domain_scores_codex":[0.9979218,0.0004101441,0.0007331126,0.0005189495,0.0001077547,0.000308187],"domain_scores_gemma":[0.9986417,0.00007507241,0.0007412998,0.0004539333,0.00003379027,0.00005418905],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002029232,0.0003789389,0.000002080578,0.008243939,0.0001854262,0.000003980707,0.0001996368,2.423371e-7,0.9350264,0.00006740091,0.000211278,0.05547776],"study_design_scores_gemma":[0.0006831558,0.0001837892,0.00002123498,0.002193864,0.000375521,0.000002268579,0.00003954237,5.353949e-8,0.6024532,0.00007986878,0.3936597,0.0003078009],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0128129,0.9849845,0.00008072908,0.000005428611,0.0003261909,0.001258674,0.0002538539,0.00004905454,0.0002286558],"genre_scores_gemma":[0.04522387,0.9467493,0.0003004462,0.000005520129,0.0000134351,0.000542365,0.0010167,0.00007071967,0.006077645],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.3934484,"threshold_uncertainty_score":0.999945,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01538433411568979,"score_gpt":0.2267075109669276,"score_spread":0.2113231768512378,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}