{"id":"W4285730617","doi":"10.1002/wsbm.1578","title":"Direct regulation of TCR rearrangement and expression by E proteins during early T cell development","year":2022,"lang":"en","type":"review","venue":"WIREs Mechanisms of Disease","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Hospital; University of Toronto; Sunnybrook Health Science Centre","funders":"Institute of Infection and Immunity; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Division of Intramural Research, National Institute of Allergy and Infectious Diseases","keywords":"T-cell receptor; Biology; Chromatin; T cell; Cell biology; Epigenetics; Recombinase; Genetics; V(D)J recombination; Genome instability; Recombination-activating gene; Allelic exclusion; Regulation of gene expression; Jurkat cells; Gene; Immune system; DNA; DNA damage","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001186544,0.0001726124,0.0001304196,0.0002526982,0.0001211487,0.000463637,0.0001173998,0.0002146987,0.001769157],"category_scores_gemma":[0.0002047188,0.0001065588,0.0001192995,0.0001613112,0.0002156344,0.0002806671,0.000334155,0.000335432,0.0006420108],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001889554,"about_ca_system_score_gemma":0.0001141116,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001797467,"about_ca_topic_score_gemma":0.0002154864,"domain_scores_codex":[0.9998152,0.00003581723,0.00001493799,0.00004806406,0.00003551109,0.00005054538],"domain_scores_gemma":[0.9998674,0.00003825512,0.00003893834,0.00001014041,0.00001709501,0.0000280986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009448692,0.00001462977,0.000466498,0.00002837388,0.000001818853,0.00009015085,0.00003163766,0.0000409189,0.9952503,0.0002803581,0.00006359185,0.003637213],"study_design_scores_gemma":[0.00002486223,0.0002461716,0.0340873,0.00002728542,0.0000144233,0.0006176972,0.0001816293,0.000765408,0.9502789,0.0003578365,0.01338922,0.000009335688],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.974381,0.01072838,0.007278432,0.0001552962,0.0000719024,0.00003391406,0.0005448916,0.0001664435,0.00663981],"genre_scores_gemma":[0.9874559,0.004475337,0.002151856,0.00008698125,0.00003069887,0.00003746655,0.0005087839,0.00004028001,0.005212615],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.001769157,"threshold_uncertainty_score":0.005918443,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01538433411568979,"score_gpt":0.2267075109669276,"score_spread":0.2113231768512378,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}