{"id":"W4285731045","doi":"10.1007/s00259-022-05897-4","title":"Reactive astrogliosis is associated with higher cerebral glucose consumption in the early Alzheimer’s continuum","year":2022,"lang":"en","type":"article","venue":"European Journal of Nuclear Medicine and Molecular Imaging","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Research, Development and Innovation Office; Horizon 2020; National Institutes of Health; Olav Thon Stiftelsen; UK Dementia Research Institute; Vetenskapsrådet; Ministerio de Ciencia e Innovación; Bundesministerium für Bildung und Forschung; Fonds National de la Recherche Luxembourg; Instituto de Salud Carlos III; Familjen Erling-Perssons Stiftelse; Stiftelsen för Gamla Tjänarinnor; ZonMw; Skåne County Council's Research and Development Foundation; Ministerio de Ciencia, Innovación y Universidades; Hjärnfonden; Tribeca Film Institute; “la Caixa” Foundation; European Commission; EU Joint Programme – Neurodegenerative Disease Research; Alzheimer's Drug Discovery Foundation; Alzheimer's Association","keywords":"Astrogliosis; Glial fibrillary acidic protein; Gliosis; Alzheimer's disease; Pathology; Cerebrospinal fluid; Internal medicine; Medicine; Pathological; Endocrinology; Temporal lobe; Astrocyte; Psychology; Neuroscience; Disease; Central nervous system; Epilepsy; Immunohistochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008968732,0.0001418129,0.0002689461,0.000205081,0.0001460515,0.00002839942,0.0001278573,0.000007875315,0.0002118673],"category_scores_gemma":[0.00006161424,0.00008814695,0.00007373193,0.0001935604,0.0001774723,0.00010914,0.00006494438,0.0005306994,0.00000663224],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005350155,"about_ca_system_score_gemma":0.0000410805,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002017852,"about_ca_topic_score_gemma":4.720449e-7,"domain_scores_codex":[0.9979478,0.0007055584,0.0002826905,0.0001620445,0.0006628557,0.0002390173],"domain_scores_gemma":[0.9992521,0.00005799848,0.0002382995,0.0001507757,0.0001124605,0.0001883886],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.009065961,0.002965875,0.609954,0.00006990844,0.02799289,0.1842052,0.03098897,0.000004954224,0.02441894,0.0003119113,0.09031493,0.01970645],"study_design_scores_gemma":[0.02131698,0.005849292,0.9396771,0.0007832836,0.003832094,0.003514545,0.006969253,0.00006584123,0.0004026123,0.00005387516,0.01725126,0.0002838477],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9763255,0.007904784,0.000007878953,0.0129395,0.00004962356,0.0002040623,0.000006729286,0.00001099857,0.002550932],"genre_scores_gemma":[0.9929344,0.0000553212,0.000077213,0.006804546,0.0000712123,0.000001789265,0.000008990134,0.00004061311,0.000005926722],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3297231,"threshold_uncertainty_score":0.3594528,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03094944028943052,"score_gpt":0.2829985240042043,"score_spread":0.2520490837147738,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}