{"id":"W4285731045","doi":"10.1007/s00259-022-05897-4","title":"Reactive astrogliosis is associated with higher cerebral glucose consumption in the early Alzheimer’s continuum","year":2022,"lang":"en","type":"article","venue":"European Journal of Nuclear Medicine and Molecular Imaging","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Research, Development and Innovation Office; Horizon 2020; National Institutes of Health; Olav Thon Stiftelsen; UK Dementia Research Institute; Vetenskapsrådet; Ministerio de Ciencia e Innovación; Bundesministerium für Bildung und Forschung; Fonds National de la Recherche Luxembourg; Instituto de Salud Carlos III; Familjen Erling-Perssons Stiftelse; Stiftelsen för Gamla Tjänarinnor; ZonMw; Skåne County Council's Research and Development Foundation; Ministerio de Ciencia, Innovación y Universidades; Hjärnfonden; Tribeca Film Institute; “la Caixa” Foundation; European Commission; EU Joint Programme – Neurodegenerative Disease Research; Alzheimer's Drug Discovery Foundation; Alzheimer's Association","keywords":"Astrogliosis; Glial fibrillary acidic protein; Gliosis; Alzheimer's disease; Pathology; Cerebrospinal fluid; Internal medicine; Medicine; Pathological; Endocrinology; Temporal lobe; Astrocyte; Psychology; Neuroscience; Disease; Central nervous system; Epilepsy; Immunohistochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003272531,0.0004185022,0.0004419469,0.001079256,0.0004746246,0.0006166265,0.00028263,0.0003734202,0.001410882],"category_scores_gemma":[0.001009569,0.0002317284,0.000252168,0.0009826388,0.0002549911,0.0002444921,0.0003541312,0.0003622532,0.000214114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002124591,"about_ca_system_score_gemma":0.0001326009,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002906127,"about_ca_topic_score_gemma":0.002510762,"domain_scores_codex":[0.9998191,0.00003979778,0.00002382577,0.00005008885,0.00003821618,0.00002890461],"domain_scores_gemma":[0.9993006,0.00007723703,0.000392118,0.00004461129,0.00008928451,0.00009619108],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006939103,0.00007803931,0.9947627,0.00002488906,0.00007712276,0.0003415968,0.0001507918,0.00003947093,0.002079812,0.00001885978,0.00005667964,0.001676015],"study_design_scores_gemma":[0.000004337842,0.00008472265,0.9989379,0.000004027508,0.00002712652,0.0004481663,0.0001160502,0.00007702492,0.0001782262,0.00005755431,0.00006205432,0.000002772192],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995782,0.0001494509,0.00004512959,0.00001006834,0.000002229572,0.000002504407,0.00006488102,0.00000274389,0.0001447705],"genre_scores_gemma":[0.999686,0.00006104794,0.00006082148,0.000005554173,0.000004323689,0.000003617366,0.00008487023,0.000001393764,0.00009237227],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002906127,"threshold_uncertainty_score":0.005778432,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03094944028943052,"score_gpt":0.2829985240042043,"score_spread":0.2520490837147738,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}