{"id":"W4285735331","doi":"10.1530/rem-22-0006","title":"Oxidative stress leads to severe phenotypes in sepsis through activation of NLRP3-pyroptosis","year":2022,"lang":"en","type":"article","venue":"Redox Experimental Medicine","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European Social Fund; INCLIVA Instituto de Investigación Sanitaria; Grand Challenges Canada; European Regional Development Fund; Generalitat Valenciana; Instituto de Salud Carlos III; Ministerio de Economía y Competitividad","keywords":"Pyroptosis; Inflammasome; Oxidative stress; Sepsis; Immunology; Phenotype; Inflammation; Medicine; Cell biology; Biology; Genetics; Internal medicine; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003671716,0.0004955877,0.0004189542,0.0004112155,0.0002957718,0.0002999633,0.0001329837,0.0004704287,0.001770058],"category_scores_gemma":[0.0002926722,0.0001472779,0.0005831586,0.000269266,0.000378467,0.0003099166,0.0005434176,0.0009380933,0.000313028],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001725437,"about_ca_system_score_gemma":0.0002230664,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001564141,"about_ca_topic_score_gemma":0.0001553437,"domain_scores_codex":[0.9997132,0.0001018766,0.00003952514,0.00004330688,0.00005085842,0.00005110385],"domain_scores_gemma":[0.9997807,0.00001366649,0.00009428217,0.00001567125,0.00002653817,0.00006915773],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001989088,0.0003353846,0.009452142,0.0008242115,0.0001198059,0.003615103,0.0002236969,0.0001660769,0.9633598,0.001015544,0.0008374217,0.01806178],"study_design_scores_gemma":[0.0006803913,0.008836783,0.415985,0.0006160573,0.0006418151,0.04376801,0.001261558,0.002812646,0.4735738,0.01308818,0.0385889,0.0001468543],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9559533,0.02804444,0.009033692,0.001579204,0.0003764206,0.0002176678,0.0005876801,0.0001588533,0.004048713],"genre_scores_gemma":[0.9867131,0.00831619,0.002406019,0.0005118577,0.00009295822,0.0001029304,0.0003392775,0.00001585361,0.001501956],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001770058,"threshold_uncertainty_score":0.005921423,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01066020454967013,"score_gpt":0.2833848962331029,"score_spread":0.2727246916834328,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}