{"id":"W4285741740","doi":"10.3389/fmolb.2022.866764","title":"Current Advances in CETSA","year":2022,"lang":"en","type":"review","venue":"Frontiers in Molecular Biosciences","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European Commission; European Federation of Pharmaceutical Industries and Associations; Diamond Light Source; Innovative Medicines Initiative; McGill University","keywords":"Proteome; Drug discovery; Chemistry; Small molecule; Computational biology; Biology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003399168,0.0003943896,0.0007207122,0.000490628,0.0001117926,0.00005194355,0.0008360942,0.0001976165,0.0000506897],"category_scores_gemma":[0.0001367898,0.0003486346,0.0003875176,0.0009336383,0.0002033282,0.00001161858,0.0003928265,0.0003636307,0.000003830473],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009442446,"about_ca_system_score_gemma":0.0003937685,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001225652,"about_ca_topic_score_gemma":0.00002201635,"domain_scores_codex":[0.9973259,0.0003621353,0.0005175468,0.0009615271,0.000351613,0.000481262],"domain_scores_gemma":[0.9991587,0.00001162924,0.0002413572,0.0004671603,0.0000136937,0.000107416],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000008127143,0.0001079008,0.0002928079,0.001070274,0.00001223486,0.00003100492,0.00001108663,0.000057055,0.00005115091,0.00002104736,0.003273912,0.9950634],"study_design_scores_gemma":[0.0001543793,0.0001398388,0.000005548267,0.0008731453,0.00003029326,0.00000855396,0.00004922816,0.00001353042,0.00007781226,0.000253812,0.9979576,0.00043624],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00008660923,0.9936746,0.001660085,0.000005940189,0.003315017,0.0004990159,0.00004885026,0.00001133608,0.0006985439],"genre_scores_gemma":[0.0000748441,0.998466,0.0008318169,0.00005987078,0.00009896753,0.0002185228,0.0001630445,0.00003265065,0.00005430437],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9946837,"threshold_uncertainty_score":0.9998966,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0152653248272438,"score_gpt":0.3273024855726585,"score_spread":0.3120371607454147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}