{"id":"W4285742386","doi":"10.3389/fphys.2022.892196","title":"Roles of Endomembrane Alkali Cation/Proton Exchangers in Synaptic Function and Neurodevelopmental Disorders","year":2022,"lang":"en","type":"review","venue":"Frontiers in Physiology","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Canada First Research Excellence Fund","keywords":"Endomembrane system; Neuroscience; Golgi apparatus; Endosome; Synaptogenesis; Endocytic cycle; Compartmentalization (fire protection); Cell biology; Synaptic vesicle; Biology; Chemistry; Vesicle; Intracellular; Cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000422669,0.0007788764,0.0008495293,0.001579842,0.000224956,0.0008819691,0.0005801002,0.0009915691,0.003954195],"category_scores_gemma":[0.0004078728,0.0001705116,0.0004329803,0.001521545,0.0003466817,0.001011701,0.0007647977,0.001490696,0.002335408],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004276145,"about_ca_system_score_gemma":0.000919956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006340224,"about_ca_topic_score_gemma":0.001418735,"domain_scores_codex":[0.9998922,0.00001502418,0.00001723642,0.00001910093,0.00003989623,0.00001640808],"domain_scores_gemma":[0.9998419,0.00006191025,0.00002323927,0.000004728332,0.00004661372,0.00002152401],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006892285,0.0000463793,0.0002480032,0.01064835,0.00007490957,0.0003037025,0.00005826223,0.0002265154,0.002429968,0.004542131,0.03036698,0.9509858],"study_design_scores_gemma":[0.00001068581,0.00005585326,0.0007803557,0.00193762,0.00009073283,0.00142784,0.00004225021,0.00006042404,0.0004654858,0.001587547,0.9935306,0.00001055964],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001562617,0.9978027,0.0001493766,0.0003073413,0.0002949706,0.000003865614,0.00002320939,0.0000104074,0.00125196],"genre_scores_gemma":[0.0008879156,0.9975705,0.0002138817,0.0001745742,0.0001911307,0.000004426081,0.00004206042,0.000001739111,0.0009137273],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003954195,"threshold_uncertainty_score":0.01322812,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01098771197478305,"score_gpt":0.229994061142838,"score_spread":0.2190063491680549,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}