{"id":"W4285795930","doi":"10.3390/cancers14143500","title":"Mutant p53, the Mevalonate Pathway and the Tumor Microenvironment Regulate Tumor Response to Statin Therapy","year":2022,"lang":"en","type":"review","venue":"Cancers","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"","keywords":"Mevalonate pathway; Mutant; Cancer research; Statin; Tumor microenvironment; Medicine; Biology; Tumor cells; Internal medicine; Biochemistry; Enzyme; Reductase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005340692,0.0005984865,0.00116371,0.001760796,0.0001757266,0.0009171858,0.0006751891,0.0009440558,0.002423603],"category_scores_gemma":[0.0007414137,0.0002116905,0.0004818614,0.001386589,0.0003297765,0.00084831,0.0005121829,0.001418136,0.001387059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006497735,"about_ca_system_score_gemma":0.0008985992,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008196102,"about_ca_topic_score_gemma":0.001939644,"domain_scores_codex":[0.9998577,0.00002936373,0.00002595032,0.00002296759,0.00004632428,0.00001760288],"domain_scores_gemma":[0.9997399,0.0001345112,0.00003438448,0.00000644697,0.00006230744,0.00002232751],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001930557,0.00007349767,0.0002466784,0.01935361,0.0001451375,0.0002196473,0.00003917103,0.0003118658,0.001809799,0.003510565,0.02722711,0.9468699],"study_design_scores_gemma":[0.00003769438,0.0001404771,0.001622049,0.005626091,0.000231178,0.001608113,0.00004947519,0.0001126564,0.0007074107,0.001841618,0.9880024,0.00002087301],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009800557,0.999018,0.00004990906,0.0002032325,0.0001260872,0.000003090225,0.00001485247,0.000003981987,0.0004828698],"genre_scores_gemma":[0.0005092277,0.9988247,0.00007989666,0.0001372269,0.0001000419,0.000004897513,0.00002328369,9.208159e-7,0.0003198644],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002423603,"threshold_uncertainty_score":0.008107781,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01786230317949751,"score_gpt":0.2698807290603452,"score_spread":0.2520184258808477,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}