{"id":"W4285795930","doi":"10.3390/cancers14143500","title":"Mutant p53, the Mevalonate Pathway and the Tumor Microenvironment Regulate Tumor Response to Statin Therapy","year":2022,"lang":"en","type":"review","venue":"Cancers","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"","keywords":"Mevalonate pathway; Mutant; Cancer research; Statin; Tumor microenvironment; Medicine; Biology; Tumor cells; Internal medicine; Biochemistry; Enzyme; Reductase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001245298,0.0004505098,0.0008003467,0.00005070399,0.0003059147,0.00005258817,0.0005824631,0.00007706593,0.000174292],"category_scores_gemma":[0.00009627508,0.0002502353,0.0003810179,0.0001542383,0.0003757733,0.000002292006,0.0003130072,0.0003089888,0.000008733826],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004014511,"about_ca_system_score_gemma":0.001251835,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001490392,"about_ca_topic_score_gemma":0.00004870994,"domain_scores_codex":[0.9972744,0.0009405511,0.0004341257,0.0006789367,0.0002647367,0.0004072634],"domain_scores_gemma":[0.9984902,0.0001258336,0.0003117471,0.0009221358,0.0000186778,0.0001314153],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003606333,0.00001718034,4.743194e-7,0.0006181565,0.0005169357,0.000004695812,0.0007479182,0.00008414562,0.007791775,0.00007468851,0.03565989,0.9508778],"study_design_scores_gemma":[0.001034952,0.000158246,0.000007813084,0.0001936721,0.0001456885,0.0000771652,0.0001708321,0.000002084258,0.000383988,0.00001425509,0.9974737,0.0003376041],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002622605,0.9909731,0.000008864296,0.0003483768,0.003677237,0.001721046,0.0005420058,0.00001003106,0.00009680198],"genre_scores_gemma":[0.00006132231,0.9907167,0.00003345172,0.002388348,0.002454493,0.001244001,0.00007845068,0.00008769587,0.002935548],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9618138,"threshold_uncertainty_score":0.999995,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01786230317949751,"score_gpt":0.2698807290603452,"score_spread":0.2520184258808477,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}