{"id":"W4285796579","doi":"10.3389/fonc.2022.935093","title":"Interplay Between Immune and Cancer-Associated Fibroblasts: A Path to Target Metalloproteinases in Penile Cancer","year":2022,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"Genital Health and Disease","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Sygehus Lillebælt; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Fundação de Amparo à Pesquisa do Estado de São Paulo; Hospital de Câncer de Barretos","keywords":"Tumor microenvironment; Immune system; Matrix metalloproteinase; Extracellular matrix; Cancer research; Biology; Stromal cell; Inflammation; Cell biology; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003374537,0.000148727,0.0006226251,0.0003353249,0.00008494048,0.000004706741,0.0001173301,0.00009561976,0.0004372268],"category_scores_gemma":[0.0001990883,0.000152951,0.00005090994,0.0004723197,0.00005449928,0.00004520231,0.0001798168,0.0003985117,0.000002573162],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001827509,"about_ca_system_score_gemma":0.0009105844,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008269621,"about_ca_topic_score_gemma":0.0017605,"domain_scores_codex":[0.9984024,0.0002193931,0.0003942665,0.0003345911,0.0001720983,0.0004772702],"domain_scores_gemma":[0.9993516,0.00006456616,0.0001025178,0.0001410559,0.00003442922,0.000305829],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002372407,0.0005347296,0.9408657,0.0002521201,0.00004546808,0.0005841206,0.002183364,0.0002094233,0.0003503078,0.00000753737,0.03063741,0.02195743],"study_design_scores_gemma":[0.00980516,0.005017715,0.8441335,0.0001410467,0.0001747154,0.00002746009,0.004411793,0.0007700761,0.0003369924,0.0008163989,0.133909,0.0004561633],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9782662,0.01566258,0.00003780138,0.003267157,0.0007344733,0.001023181,0.0003351009,0.00002760553,0.0006459188],"genre_scores_gemma":[0.9938984,0.00005601496,0.001954409,0.001542681,0.00007449046,0.001336858,0.00009199097,0.0000214367,0.001023702],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1032716,"threshold_uncertainty_score":0.9983344,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01288722781463503,"score_gpt":0.3399279330600352,"score_spread":0.3270407052454001,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}