{"id":"W4285798648","doi":"10.2217/fon-2022-0450","title":"Design of the VIALE-M phase III trial of venetoclax and oral azacitidine maintenance therapy in acute myeloid leukemia","year":2022,"lang":"en","type":"review","venue":"Future Oncology","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre","funders":"AbbVie","keywords":"Venetoclax; Medicine; Azacitidine; Myeloid leukemia; Internal medicine; Oncology; Maintenance therapy; Minimal residual disease; Leukemia; Chemotherapy; Chronic lymphocytic leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001799772,0.0005031069,0.003931088,0.0004261374,0.00007836581,0.000005835715,0.0007074216,0.0008526852,0.0005263799],"category_scores_gemma":[0.0002277906,0.0003080666,0.000492184,0.00104928,0.0005430635,0.00004245441,0.0003774235,0.002078464,0.000003296205],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.004186053,"about_ca_system_score_gemma":0.01216419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001313413,"about_ca_topic_score_gemma":0.00002793689,"domain_scores_codex":[0.9952005,0.00178752,0.001304574,0.0006033603,0.0005374849,0.0005665639],"domain_scores_gemma":[0.9969625,0.0009623737,0.0009734917,0.000850975,0.0001135371,0.0001370618],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.04898601,0.0003151164,0.00000149186,0.002113289,0.0006540946,0.0003561116,0.0003059733,0.000004269189,0.0002015104,0.0001431069,0.006245603,0.9406734],"study_design_scores_gemma":[0.1018674,0.007630353,0.000004146212,0.001116859,0.000648367,0.0005658072,0.00009057939,0.00004516665,0.00003879292,0.00003362601,0.8877555,0.0002033255],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001912165,0.9872394,0.00006054122,0.0005504409,0.001165551,0.008055661,0.0001563112,0.00002327547,0.0008366765],"genre_scores_gemma":[0.0001185558,0.9960525,0.0007368097,0.0002359076,0.0009105151,0.0007484359,0.0001331044,0.00008632545,0.0009778598],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9404701,"threshold_uncertainty_score":0.9999371,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07129580869837542,"score_gpt":0.394829134396921,"score_spread":0.3235333256985455,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}