{"id":"W4285798648","doi":"10.2217/fon-2022-0450","title":"Design of the VIALE-M phase III trial of venetoclax and oral azacitidine maintenance therapy in acute myeloid leukemia","year":2022,"lang":"en","type":"review","venue":"Future Oncology","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre","funders":"AbbVie","keywords":"Venetoclax; Medicine; Azacitidine; Myeloid leukemia; Internal medicine; Oncology; Maintenance therapy; Minimal residual disease; Leukemia; Chemotherapy; Chronic lymphocytic leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002354484,0.0006447856,0.002186925,0.000275533,0.0001515831,0.0008693901,0.0007787573,0.001014072,0.005431402],"category_scores_gemma":[0.001490799,0.0002536959,0.001431606,0.000424772,0.0003249813,0.0004920292,0.0003045276,0.001895132,0.0009459119],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005397124,"about_ca_system_score_gemma":0.001260555,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005951949,"about_ca_topic_score_gemma":0.001830026,"domain_scores_codex":[0.9995642,0.0002377337,0.00003554212,0.00006400108,0.00005497925,0.00004361282],"domain_scores_gemma":[0.9997764,0.00006794326,0.00005611072,0.00001681734,0.00003039901,0.00005230942],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.2809656,0.004305576,0.001394278,0.07337528,0.01293838,0.000286664,0.0002166121,0.002207943,0.007562292,0.00627341,0.02762539,0.5828485],"study_design_scores_gemma":[0.8306724,0.04111808,0.003910271,0.008119592,0.01029992,0.0003388456,0.00008240255,0.00105585,0.001413416,0.002136069,0.1007889,0.00006423984],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"protocol","genre_scores_codex":[0.1161217,0.8073002,0.00464833,0.005225246,0.005505699,0.03680767,0.004384319,0.0002474953,0.01975943],"genre_scores_gemma":[0.3695744,0.5243582,0.01261147,0.01256108,0.001560575,0.04928235,0.003828085,0.00008437491,0.02613951],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.005431402,"threshold_uncertainty_score":0.01816988,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07129580869837542,"score_gpt":0.394829134396921,"score_spread":0.3235333256985455,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}