{"id":"W4285799750","doi":"10.2196/36100","title":"Development of a Multiepitope Vaccine Against SARS-CoV-2: Immunoinformatics Study","year":2022,"lang":"en","type":"article","venue":"JMIR Bioinformatics and Biotechnology","topic":"vaccines and immunoinformatics approaches","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Epitope; Virology; Biology; Major histocompatibility complex; MHC class I; Antibody; Outbreak; Pandemic; Virus; Computational biology; Antigen; Coronavirus disease 2019 (COVID-19); Immunology; Medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003396761,0.0004922881,0.0005395284,0.0003907189,0.0002281871,0.0004734487,0.0003761354,0.000530324,0.001651175],"category_scores_gemma":[0.000397013,0.0001667836,0.0005542653,0.0002774722,0.0001503878,0.0004787518,0.0002566,0.0004099639,0.0001923225],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003977521,"about_ca_system_score_gemma":0.0008540298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001032301,"about_ca_topic_score_gemma":0.0009987772,"domain_scores_codex":[0.9998975,0.00002912943,0.000005141189,0.00002517281,0.00002616303,0.00001692161],"domain_scores_gemma":[0.999853,0.0000740166,0.00002064829,0.000006322851,0.00002885651,0.00001721276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0002707724,0.0007309579,0.00765781,0.0004059921,0.0001221234,0.000373572,0.00004824009,0.9004586,0.04660292,0.006337214,0.001135769,0.03585608],"study_design_scores_gemma":[0.00003477188,0.0002986775,0.0008280489,0.00001392197,0.000036506,0.0000803744,0.00003380842,0.9886524,0.007462258,0.001375323,0.001176202,0.000007684574],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8114864,0.002542428,0.1740761,0.001305166,0.0001184061,0.0001762138,0.0004678384,0.000372219,0.00945522],"genre_scores_gemma":[0.8779418,0.002275911,0.1163089,0.0003641859,0.0000530154,0.0001676904,0.0008945111,0.00003781071,0.001956139],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001651175,"threshold_uncertainty_score":0.005523682,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01514851900584124,"score_gpt":0.2529993424667979,"score_spread":0.2378508234609567,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}