{"id":"W4285802297","doi":"10.2174/1568026622666220718155616","title":"Indoleamine 2,3-dioxygenase (IDO)-activity in Severe Psychiatric Disorders:A Systemic Review","year":2022,"lang":"en","type":"review","venue":"Current Topics in Medicinal Chemistry","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"","keywords":"Kynurenine; Kynurenine pathway; Bipolar disorder; Schizophrenia (object-oriented programming); Indoleamine 2,3-dioxygenase; Depression (economics); Psychiatry; Medicine; Major depressive disorder; Psychosis; Internal medicine; Clinical psychology; Tryptophan; Cognition; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001249221,0.0009569588,0.002814891,0.005708477,0.0003456965,0.001508243,0.000927776,0.001166305,0.002443],"category_scores_gemma":[0.003168825,0.000413564,0.002065928,0.00550134,0.0004050141,0.00111262,0.000670654,0.0007797108,0.0003518273],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008685357,"about_ca_system_score_gemma":0.003799435,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002391222,"about_ca_topic_score_gemma":0.004651173,"domain_scores_codex":[0.9994301,0.0001304467,0.0002028115,0.00008605655,0.0001136872,0.00003690876],"domain_scores_gemma":[0.9971581,0.001969669,0.0004590055,0.00003888564,0.0003129053,0.00006157441],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0002259356,0.00005161386,0.00100109,0.6052416,0.001751298,0.0002884493,0.0002501929,0.0002858983,0.0009665134,0.000997971,0.01106582,0.3778736],"study_design_scores_gemma":[0.0001177551,0.0005503825,0.01123736,0.5283676,0.02058623,0.004018454,0.0005992366,0.0002755052,0.0009074577,0.002107349,0.4311458,0.0000868453],"study_design_candidate":"systematic_review","study_design_consensus":"systematic_review","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001305661,0.9995996,0.00002388947,0.00007262114,0.00005282288,0.000005124784,0.00002442865,0.000001714678,0.00008914258],"genre_scores_gemma":[0.001226967,0.9984378,0.00009557782,0.00009937857,0.00005627122,0.0000101535,0.00002762961,6.907741e-7,0.00004546209],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005708477,"threshold_uncertainty_score":0.008172631,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06987022219642954,"score_gpt":0.3569039863909845,"score_spread":0.287033764194555,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}