{"id":"W4285802660","doi":"10.1101/2022.07.18.499263","title":"An autoregulatory feedback loop converging on H2A ubiquitination drives synovial sarcoma","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Sarcoma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Coastal Health; Vancouver Coastal Health Research Institute; University of British Columbia","funders":"National Cancer Institute; National Institutes of Health; European Commission; Deutsches Krebsforschungszentrum; Memorial Sloan-Kettering Cancer Center; Terry Fox Research Institute; Howard Hughes Medical Institute","keywords":"Synovial sarcoma; Chromatin; Ubiquitin; Histone; Cell biology; Fusion protein; Epigenetics; Chromatin remodeling; Biology; Cancer research; Gene; Genetics; Sarcoma; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001096538,0.0001955028,0.0001144118,0.0001508353,0.0001007208,0.000216169,0.000121958,0.0001279799,0.002019403],"category_scores_gemma":[0.0001532564,0.000129721,0.0001197337,0.00008239935,0.0001959222,0.0001268295,0.0002609073,0.0002175436,0.0005889258],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003120843,"about_ca_system_score_gemma":0.0001662393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000404388,"about_ca_topic_score_gemma":0.000399857,"domain_scores_codex":[0.9999144,0.00001353735,0.00000570349,0.0000215474,0.0000271196,0.00001756077],"domain_scores_gemma":[0.999907,0.00001446338,0.00002769004,0.00001348913,0.00001043772,0.00002686561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007867767,0.00000825703,0.0005563106,0.000007213974,0.000001669862,0.0000622809,0.000006379474,0.0001261729,0.9979349,0.0001819746,0.00005279852,0.0009833463],"study_design_scores_gemma":[0.00002150094,0.0001269205,0.007661973,0.000002646143,0.00000644,0.0003599905,0.00002604382,0.004732984,0.9850787,0.0002195063,0.001759416,0.000003921794],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929333,0.0002689116,0.005055601,0.00007505295,0.00001649962,0.000008679164,0.000129503,0.0001975421,0.001315043],"genre_scores_gemma":[0.9977098,0.00005660849,0.0009349229,0.00001554526,0.000004378474,0.000004537358,0.00008463011,0.00001040321,0.00117925],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002019403,"threshold_uncertainty_score":0.00675559,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01612009982785264,"score_gpt":0.2547800649315426,"score_spread":0.23865996510369,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}