{"id":"W4285807482","doi":"10.1002/jia2.25917","title":"Clinical and population‐based study design considerations to accelerate the investigation of new antiretrovirals during pregnancy","year":2022,"lang":"en","type":"article","venue":"Journal of the International AIDS Society","topic":"Pregnancy and Medication Impact","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Membrane Reactor Technologies (Canada)","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"Medicine; Pregnancy; Observational study; Dosing; Population; Clinical endpoint; Randomized controlled trial; Clinical trial; Clinical study design; Adverse effect; Gestational age; Research design; Intensive care medicine; Obstetrics; Pediatrics; Internal medicine; Environmental health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.5655578,0.002286927,0.004587381,0.003531766,0.001997069,0.007615936,0.005113955,0.007458002,0.01911381],"category_scores_gemma":[0.5894668,0.002907288,0.005556481,0.006072628,0.002989122,0.008399865,0.004765983,0.0073236,0.004477304],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003490669,"about_ca_system_score_gemma":0.01485618,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001140974,"about_ca_topic_score_gemma":0.002525309,"domain_scores_codex":[0.2415394,0.7048646,0.03160452,0.004495766,0.01617093,0.001324786],"domain_scores_gemma":[0.3240126,0.4752747,0.0587126,0.07037868,0.0641626,0.00745878],"domain_codex":"methods","domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.08214498,0.003233628,0.04299859,0.05775728,0.01468704,0.0008977135,0.004041514,0.009459631,0.004128429,0.08042295,0.1679314,0.5322969],"study_design_scores_gemma":[0.09614731,0.02963559,0.07890624,0.06872743,0.01183225,0.001745757,0.001425984,0.02007578,0.007130935,0.1184624,0.5651165,0.0007938088],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"protocol","genre_gemma":"methods","genre_scores_codex":[0.02606501,0.03529852,0.3746932,0.09167708,0.03489191,0.388747,0.0086674,0.002126175,0.03783371],"genre_scores_gemma":[0.07640483,0.00437105,0.4047415,0.01750285,0.004986297,0.4879776,0.001049235,0.0003416094,0.002625093],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.5655578,"threshold_uncertainty_score":0.5357445,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.116070135426943,"score_gpt":0.3775325116067247,"score_spread":0.2614623761797816,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}