{"id":"W4285808590","doi":"10.1016/j.jbc.2022.102277","title":"The amino acid sensor GCN2 suppresses terminal oligopyrimidine (TOP) mRNA translation via La-related protein 1 (LARP1)","year":2022,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill Genome Centre; McGill University; University of Toronto; McGill University Health Centre","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Heart, Lung, and Blood Institute; National Institutes of Health; Chicago Biomedical Consortium","keywords":"Messenger RNA; Translation (biology); Cell biology; Protein biosynthesis; EIF4E; Chromatin immunoprecipitation; Biology; Molecular biology; Chemistry; Gene expression; Promoter; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007622014,0.0003590141,0.0003258605,0.0001443116,0.0001645498,0.0002656958,0.0002198215,0.0002566729,0.001322387],"category_scores_gemma":[0.00008782727,0.0001542154,0.0002969466,0.0001089135,0.0001887674,0.0001748742,0.0003228256,0.0004640858,0.0003204809],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000437244,"about_ca_system_score_gemma":0.0002909096,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001580795,"about_ca_topic_score_gemma":0.002894929,"domain_scores_codex":[0.9998783,0.000008946235,0.000007930847,0.00004675232,0.00003329326,0.00002479705],"domain_scores_gemma":[0.9999408,0.000006621502,0.0000205551,0.000005030249,0.000007324241,0.00001984829],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007493108,0.000005796349,0.0002142246,0.00003522817,0.000003538564,0.00003261301,0.000004474972,0.00004508129,0.9988874,0.0000399411,0.00006565716,0.000591136],"study_design_scores_gemma":[0.00001625795,0.00008461485,0.01019153,0.000007318912,0.00001679241,0.000205131,0.0000265703,0.002047904,0.9834508,0.00005948449,0.003886354,0.000007163716],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987632,0.003205471,0.003777517,0.0003075031,0.00009548276,0.00002267771,0.002450407,0.0003018607,0.002207038],"genre_scores_gemma":[0.9895635,0.001143406,0.002720519,0.0002474955,0.00001904826,0.00004351864,0.002243988,0.00006874183,0.003949813],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001580795,"threshold_uncertainty_score":0.004423857,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0155879571421588,"score_gpt":0.2537251802860711,"score_spread":0.2381372231439123,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}