{"id":"W4285808620","doi":"10.1016/j.neuroscience.2022.07.014","title":"Differential Regulation of Tau Exon 2 and 10 Isoforms in Huntington’s Disease Brain","year":2022,"lang":"en","type":"article","venue":"Neuroscience","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre intégré universitaire de santé et de services sociaux de la Capitale-Nationale; Institut Universitaire en Santé Mentale de Québec; Université Laval; Centres Intégré Universitaires de Santé et de Services Sociaux; Centre hospitalier de l'Université Laval","funders":"National Institute on Drug Abuse; Agence Nationale de la Recherche","keywords":"Exon; Neurodegeneration; Tauopathy; Huntington's disease; Huntingtin; Alternative splicing; Biology; Putamen; Gene isoform; RNA splicing; Genetics; Neuroscience; Internal medicine; Gene; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002068512,0.0002567432,0.0002288996,0.0004793761,0.0002769558,0.0003720869,0.0001719694,0.0003111479,0.001075033],"category_scores_gemma":[0.0001917978,0.0001803355,0.0002282004,0.0001314977,0.0002974453,0.0002837083,0.0002228615,0.0003228881,0.00021879],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003624021,"about_ca_system_score_gemma":0.0001786213,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009261012,"about_ca_topic_score_gemma":0.002090922,"domain_scores_codex":[0.9998375,0.00002567946,0.00001644092,0.00004261276,0.00003024344,0.00004745344],"domain_scores_gemma":[0.999856,0.00002886365,0.0000411675,0.000009445806,0.00003127933,0.00003332257],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008424493,0.00004094105,0.005131006,0.00003491988,0.00002391771,0.0005823107,0.0001857141,0.00007190243,0.9897937,0.000346198,0.0001114371,0.00283555],"study_design_scores_gemma":[0.0001005614,0.0007604857,0.5730889,0.00005824502,0.0001121573,0.005049434,0.0008692667,0.001609215,0.4130207,0.001615373,0.003682391,0.00003319923],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979504,0.0007990445,0.0003028412,0.00003871734,0.00001364285,0.000002636442,0.00006878757,0.000008476842,0.0008153884],"genre_scores_gemma":[0.9967926,0.0004943126,0.0004768869,0.0000539332,0.00000882829,0.00001160989,0.0002124214,0.000012411,0.001936969],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001075033,"threshold_uncertainty_score":0.003596306,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02361995073691724,"score_gpt":0.2580171280397301,"score_spread":0.2343971773028129,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}