{"id":"W4285823231","doi":"10.32604/or.2022.03529","title":"cGAS regulates the DNA damage response to maintain proliferative signaling in gastric cancer cells","year":2021,"lang":"en","type":"article","venue":"Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Key Research and Development Program of China; Zhengzhou University","keywords":"Cancer; Genome instability; Cancer research; DNA damage; Cancer cell; Biology; Gene silencing; Ectopic expression; Cell growth; Downregulation and upregulation; Metastasis; Tumor progression; Cell biology; Cell culture; DNA; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001186798,0.0002368203,0.0002065906,0.0003680705,0.0002200832,0.0004189804,0.0001612636,0.0002161329,0.001482792],"category_scores_gemma":[0.0001259393,0.00009432247,0.0002876017,0.0003180687,0.0001757925,0.000195782,0.0002285117,0.0003601455,0.0005009114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005267512,"about_ca_system_score_gemma":0.0003492245,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00151248,"about_ca_topic_score_gemma":0.00185883,"domain_scores_codex":[0.9998715,0.00001254229,0.000007843931,0.00003874587,0.00004204093,0.00002727054],"domain_scores_gemma":[0.9999411,0.000004106746,0.0000209212,0.000007227773,0.00001285621,0.00001374784],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001511198,0.00002512587,0.001187751,0.00009329351,0.00001285557,0.00008569565,0.00002739222,0.0001959645,0.990272,0.0004496932,0.0002998561,0.007199168],"study_design_scores_gemma":[0.00005452131,0.0003454355,0.0534585,0.00003222509,0.0001015907,0.0006693365,0.0001422364,0.005978991,0.9048755,0.000745433,0.03356922,0.00002696032],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9640363,0.01478598,0.008276648,0.0005000228,0.00011637,0.00009898923,0.002596849,0.0006048076,0.00898398],"genre_scores_gemma":[0.9907516,0.002339401,0.002273809,0.0001231025,0.00001355263,0.00004366523,0.001458735,0.00002202185,0.002974103],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00151248,"threshold_uncertainty_score":0.004960418,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1582064670932602,"score_gpt":0.497036857738369,"score_spread":0.3388303906451088,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}