{"id":"W4285992810","doi":"10.1056/nejmoa2202809","title":"Pembrolizumab plus Chemotherapy in Advanced Triple-Negative Breast Cancer","year":2022,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":1096,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Merck","keywords":"Pembrolizumab; Triple-negative breast cancer; Medicine; Chemotherapy; Breast cancer; Oncology; Internal medicine; Cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001252286,0.0005650551,0.00156789,0.0003039281,0.0002526343,0.0003888934,0.0003653907,0.0004496436,0.002977942],"category_scores_gemma":[0.0008485641,0.0002203873,0.0007725316,0.0002428586,0.0003423441,0.0003105915,0.0002369075,0.001234822,0.0004120509],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004620672,"about_ca_system_score_gemma":0.0009067251,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004399262,"about_ca_topic_score_gemma":0.001094526,"domain_scores_codex":[0.9996449,0.0001991714,0.0000233402,0.00004474305,0.00003315218,0.00005467512],"domain_scores_gemma":[0.9995758,0.0001111455,0.0001089592,0.00003338463,0.00002323421,0.0001475575],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8913039,0.009872115,0.002695599,0.000665308,0.0008374465,0.00007359299,0.00006611755,0.001173496,0.008689898,0.0001902179,0.001066621,0.08336572],"study_design_scores_gemma":[0.7555281,0.2259119,0.01159621,0.00009554996,0.000788008,0.0001557898,0.00002235621,0.0007424082,0.002597424,0.0002548407,0.002294243,0.00001309347],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930584,0.002638051,0.0003275978,0.0003413812,0.0001545119,0.001841613,0.0002556447,0.00003312109,0.001349682],"genre_scores_gemma":[0.9925246,0.001965788,0.0009882627,0.0003832349,0.0001818278,0.002655157,0.0002993031,0.000006267493,0.0009956866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002977942,"threshold_uncertainty_score":0.009962201,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01369630633823049,"score_gpt":0.2953716532372217,"score_spread":0.2816753468989912,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}