{"id":"W4286005608","doi":"10.1007/s11307-022-01754-w","title":"Detection and Typing of Renal Amyloidosis by Fluorescence Spectroscopy Using the Environmentally Sensitive Fluorophore K114","year":2022,"lang":"en","type":"article","venue":"Molecular Imaging and Biology","topic":"Amyloidosis: Diagnosis, Treatment, Outcomes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hotchkiss Brain Institute; University of Calgary","funders":"Alberta Prion Research Institute; Krembil Foundation","keywords":"Congo red; Pathology; Amyloidosis; Amyloid (mycology); Staining; Autofluorescence; Chemistry; Fluorophore; AL amyloidosis; Fluorescence; Medicine; Biology; Immunoglobulin light chain; Antibody; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000590606,0.0001778002,0.000284087,0.0005043545,0.0001879665,0.0004054885,0.0001759206,0.0005863528,0.0006603984],"category_scores_gemma":[0.001186103,0.0001116797,0.0001777545,0.0002294424,0.0001996528,0.0001898526,0.0001946733,0.0004112814,0.0002170625],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002289009,"about_ca_system_score_gemma":0.0001978387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000532688,"about_ca_topic_score_gemma":0.000658861,"domain_scores_codex":[0.999426,0.0001856778,0.00003272236,0.00007675203,0.0001921926,0.00008669675],"domain_scores_gemma":[0.9994478,0.0001888266,0.0001938357,0.00003156771,0.00009484154,0.00004309275],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002946413,0.0005186033,0.1856385,0.0001076701,0.00007662753,0.0005803541,0.0002135884,0.0006492843,0.7591552,0.0002753599,0.0004540501,0.04938424],"study_design_scores_gemma":[0.00004958179,0.002253324,0.1905225,0.00003226416,0.0001200384,0.003809985,0.0001991723,0.003915449,0.7974029,0.0003949635,0.001265329,0.00003438809],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994415,0.0007085189,0.003316653,0.0001328914,0.00001154069,0.00001701678,0.00006904532,0.00005206142,0.001277136],"genre_scores_gemma":[0.9963013,0.000262819,0.002571154,0.0000470129,0.000005636399,0.000008656141,0.00005177603,0.000007862393,0.0007438447],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006603984,"threshold_uncertainty_score":0.003123462,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006541770014818505,"score_gpt":0.2403919640819418,"score_spread":0.2338501940671233,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}