{"id":"W4286005722","doi":"10.1038/s41467-022-31794-3","title":"Kinesin-8-specific loop-2 controls the dual activities of the motor domain according to tubulin protofilament shape","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; U.S. Department of Health and Human Services; National Institutes of Health; Government of Canada; Agouron Institute; Simons Foundation","keywords":"Microtubule; Kinesin; Tubulin; Biophysics; Motor protein; Cell biology; Motility; Chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004935425,0.0002002986,0.00009953469,0.00006025794,0.0001015432,0.0002170137,0.0002729508,0.0001757446,0.0007158325],"category_scores_gemma":[0.000117171,0.00013104,0.0001238985,0.00005672294,0.0001377807,0.0001861168,0.0001586677,0.0002457356,0.0002527852],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002766686,"about_ca_system_score_gemma":0.0001834761,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008634622,"about_ca_topic_score_gemma":0.001856442,"domain_scores_codex":[0.9999568,0.000003021733,0.000002036577,0.00001326514,0.00001092179,0.00001389934],"domain_scores_gemma":[0.9999352,0.000008326074,0.00002076745,0.000009163881,0.00001083954,0.00001573607],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006307522,0.000006111732,0.0006187758,0.00001222455,0.000002378011,0.00003747244,0.0000111234,0.0002894275,0.99803,0.0001201324,0.00003986072,0.0007694523],"study_design_scores_gemma":[0.00002896779,0.00006393407,0.01968681,0.000005008721,0.000007485119,0.0002030868,0.00003339449,0.007330592,0.9711704,0.0002088886,0.001251078,0.00001029617],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997999,0.000128338,0.001055621,0.00002175393,0.000005751565,0.000004776376,0.00007866156,0.00005035459,0.0006557459],"genre_scores_gemma":[0.9982241,0.00008253994,0.0009018575,0.00001630703,0.000002096378,0.000006184919,0.0001332757,0.00001143576,0.0006221592],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008634622,"threshold_uncertainty_score":0.002394676,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01208360595567645,"score_gpt":0.2633235687044343,"score_spread":0.2512399627487578,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}